Genomics-based timely detection of dengue virus type I genotypes I and V in Uruguay
Noelia Morel,
Marta Giovanetti,
Vagner Fonseca,
Analía Burgueño,
Mauricio Lima,
Emerson Castro,
Natália R. Guimarães,
Felipe C.M. Iani,
Victoria Bormida,
Maria Noel Cortinas,
Viviana Ramas,
Leticia Coppola,
Ana I. Bento,
Alexander Rosewell,
Leticia Franco,
Jairo Mendez Rico,
José Lourenço,
Luiz Carlos Junior Alcantara,
Hector Chiparelli
Affiliations
Noelia Morel
Laboratorio de Virus Emergentes/reemergentes. Unidad de Virología, Departamento de Laboratorios de Salud Pública, Portugal; Department of Exact and Earth Sciences, University of the State of Bahia, Salvador, Brazil; Unidad de Virología. Depto. De Laboratorios de Salud Pública, Uruguay
Marta Giovanetti
Sciences and Technologies for Sustainable Development and One Health, Universita Campus Bio-Medico di Roma, Italy; Instituto Rene Rachou, Fundação Oswaldo Cruz, Minas Gerais, Brazil; Climate Amplified Diseases and Epidemics (CLIMADE), Brazil, Americas; Corresponding author. Sciences and Technologies for Sustainable Development and One Health, Universita Campus Bio-Medico di Roma, Italy.
Vagner Fonseca
Instituto Rene Rachou, Fundação Oswaldo Cruz, Minas Gerais, Brazil; Climate Amplified Diseases and Epidemics (CLIMADE), Brazil, Americas; Coordenação de Vigilância, Preparação e Resposta à Emergências e Desastres (PHE), Organização Pan-Americana da Saúde / Organização Mundial da Saúde (OPAS/OMS), Brasília, DF, Brazil
Analía Burgueño
Laboratorio de Virus Emergentes/reemergentes. Unidad de Virología, Departamento de Laboratorios de Salud Pública, Portugal
Mauricio Lima
Laboratorio Central de Saúde Pública do Estado de Minas Gerais, Fundação Ezequiel Dias, Brazil
Emerson Castro
Laboratorio Central de Saúde Pública do Estado de Minas Gerais, Fundação Ezequiel Dias, Brazil
Natália R. Guimarães
Laboratorio Central de Saúde Pública do Estado de Minas Gerais, Fundação Ezequiel Dias, Brazil
Felipe C.M. Iani
Laboratorio Central de Saúde Pública do Estado de Minas Gerais, Fundação Ezequiel Dias, Brazil
Victoria Bormida
Unidad de Genómica. Depto. De Laboratorios de Salud Pública, Uruguay
Maria Noel Cortinas
Unidad de Genómica. Depto. De Laboratorios de Salud Pública, Uruguay
Viviana Ramas
Laboratorio de Virus Respiratorios, Unidad de Virología. Departamento de Laboratorios de Salud Pública, Uruguay
Leticia Coppola
Laboratorio de Virus Respiratorios, Unidad de Virología. Departamento de Laboratorios de Salud Pública, Uruguay
Ana I. Bento
Pandemic Prevention Initiative, The Rockefeller Foundation, Washington DC, USA
Alexander Rosewell
Coordenação de Vigilância, Preparação e Resposta à Emergências e Desastres (PHE), Organização Pan-Americana da Saúde / Organização Mundial da Saúde (OPAS/OMS), Brasília, DF, Brazil
Leticia Franco
Infectious Hazards Management, Health Emergencies Department (PHE), Pan American Health Organization / World Health Organization (PAHO/WHO), Washington DC, USA
Jairo Mendez Rico
Infectious Hazards Management, Health Emergencies Department (PHE), Pan American Health Organization / World Health Organization (PAHO/WHO), Washington DC, USA
José Lourenço
BioISI (Biosystems and Integrative Sciences Institute), Faculdade de Ciências da Universidade de Lisboa, Portugal; Católica Biomedical Research Centre, Católica Medical School, Universidade Católica Portuguesa, Portugal; Climate Amplified Diseases and Epidemics (CLIMADE), Europe, Portugal
Luiz Carlos Junior Alcantara
Instituto Rene Rachou, Fundação Oswaldo Cruz, Minas Gerais, Brazil; Climate Amplified Diseases and Epidemics (CLIMADE), Brazil, Americas; Corresponding author. Instituto Rene Rachou, Fundação Oswaldo Cruz, Minas Gerais, Brazil
Hector Chiparelli
Laboratorio de Virus Emergentes/reemergentes. Unidad de Virología, Departamento de Laboratorios de Salud Pública, Portugal; Coordenação de Vigilância, Preparação e Resposta à Emergências e Desastres (PHE), Organização Pan-Americana da Saúde / Organização Mundial da Saúde (OPAS/OMS), Brasília, DF, Brazil; Corresponding author. Laboratorio de Virus Emergentes/reemergentes. Unidad de Virología, Departamento de Laboratorios de Salud Pública, Brazil
This study details a genomics-based approach for the early detection of mosquito-borne pathogens, marked by Uruguay's first ever complete genomic sequencing of Dengue Virus type I genotypes I and V. This pioneering effort has facilitated the prompt identification of these genotypes within the country, enabling Uruguayan public health authorities to develop timely and effective response strategies. Further integrated into this approach is a climate-driven suitability measure, closely associated with Dengue case reports and indicative of the local climate's role in the virus's transmission in the country within the changing climate context. The detection of multiple DENV-1 genotypes co-circulating in Uruguay underscores the necessity for proactive surveillance, particularly at borders, to prevent the introduction and dissemination of novel viral strains within the country and the region. This approach aids in facilitating prompt public health responses and intervention strategies, which are crucial in mitigating the impact of dengue outbreaks.
