Journal of International Medical Research (Jan 2020)

Simulation of key interventions for seasonal influenza outbreak control at school in Changsha, China

  • Tianmu Chen,
  • Bin Zhao,
  • Ruchun Liu,
  • Xixing Zhang,
  • Zhi Xie,
  • Shuilian Chen

DOI
https://doi.org/10.1177/0300060518764268
Journal volume & issue
Vol. 48

Abstract

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Objective To use a mathematical model to simulate an influenza outbreak in a school in order to assess the effectiveness of isolation (Iso), antiviral therapeutics, antiviral prophylactics (P), vaccination prior to the outbreak, and school closure (for 1 [S1w], 2 or 3 weeks). Methods This study developed a susceptible–exposed–infectious/asymptomatic–recovered model to estimate the effectiveness of commonly used interventions for seasonal influenza outbreaks in school. Results The most effective single-intervention strategy was isolation with a total attack rate of 1.99% and an outbreak duration of 30 days. The additional effectiveness of antiviral therapeutics and prophylactics and vaccination (prior to the outbreak) strategies were not obvious. Although Iso+P, P+Iso+S1w, four-, and five-combined intervention strategies had commendable effectiveness, total attack rate decreased only slightly, and outbreak duration was shortened by 9 days maximum, compared with the single-intervention isolation strategy. School closure for 1, 2 or 3 weeks was futile or even counterproductive. Conclusion Isolation, as a single intervention, was the most effective in terms of reducing the total attack rate and the duration of the outbreak.