The lupus susceptibility allele DRB1*03:01 encodes a disease-driving epitope

Bruna Miglioranza Scavuzzi; Vincent van Drongelen; Bhavneet Kaur; Jennifer Callahan Fox; Jianhua Liu; Raquel A. Mesquita-Ferrari; J. Michelle Kahlenberg; Evan A. Farkash; Fernando Benavides; Frederick W. Miller; Amr H. Sawalha; Joseph Holoshitz

doi:10.1038/s42003-022-03717-x

Communications Biology (Jul 2022)

The lupus susceptibility allele DRB1*03:01 encodes a disease-driving epitope

Bruna Miglioranza Scavuzzi,
Vincent van Drongelen,
Bhavneet Kaur,
Jennifer Callahan Fox,
Jianhua Liu,
Raquel A. Mesquita-Ferrari,
J. Michelle Kahlenberg,
Evan A. Farkash,
Fernando Benavides,
Frederick W. Miller,
Amr H. Sawalha,
Joseph Holoshitz

Affiliations

Bruna Miglioranza Scavuzzi: Department of Internal Medicine, University of Michigan
Vincent van Drongelen: Department of Internal Medicine, University of Michigan
Bhavneet Kaur: Department of Internal Medicine, University of Michigan
Jennifer Callahan Fox: Department of Internal Medicine, University of Michigan
Jianhua Liu: Department of Internal Medicine, University of Michigan
Raquel A. Mesquita-Ferrari: Department of Internal Medicine, University of Michigan
J. Michelle Kahlenberg: Department of Internal Medicine, University of Michigan
Evan A. Farkash: Department of Pathology, University of Michigan
Fernando Benavides: Department of Epigenetics and Molecular Carcinogenesis, MD Anderson Cancer Center
Frederick W. Miller: Environmental Autoimmunity Group, National Institute of Environmental Health Sciences
Amr H. Sawalha: Department of Internal Medicine, University of Michigan
Joseph Holoshitz: Department of Internal Medicine, University of Michigan

DOI: https://doi.org/10.1038/s42003-022-03717-x
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 15

Abstract

Read online

In the presence of IFN-γ, a short DRB1*03:01-encoded allelic epitope is found to activate a characteristic lupus transcriptome in macrophages and trigger a cascade of systemic lupus erythematosus-associated cellular aberrations.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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