Туберкулез и болезни лёгких (Mar 2014)

GENETIC STRUCTURE AND DRUG RESISTANCE OF MYCOBACTERIUM TUBERCULOSIS POPULATION IN THE CIVIL SECTOR OF THE KYRGYZ REPUBLIC

  • Zh. T. Isakova,
  • I. V. Mokrousov,
  • N. Rastogi,
  • A. A. Aldashev

Journal volume & issue
Vol. 0, no. 3
pp. 54 – 58

Abstract

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The genetic structure of drug-resistant and drug-susceptible Mycobacterium tuberculosis (MBT) circulating in the civil sector of the Kyrgyz Republic was analyzed. One hundred and three MBT DNA samples isolated from the expectoration of patients with new-onset pulmonary tuberculosis were examined. MBT was genotyped by the spoligotyping method; its resistance to rifampicin and isoniazid was determined using a TB-Biochip kit. The TB population circulating in the Kyrgyz Republic was characterized by a predominance of Beijing family strains (59.2%). The other strains represented the following families: Т (n = 14), LAM (n = 9), Ural-1 (n = 3), Ural-2 (n = 6), and others (n = 9). Multidrug-resistant strains were statistically significantly more frequently found in the genetic Beijing family than in other genotypes (p = 0.03). Thus, the circulation of drug-resistant Beijing MBT strains is a major factor that complicates the current tuberculosis situation in the Kyrgyz Republic.

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