Bangladesh Journal of Pharmacology (Jun 2015)

Antiviral mode of action of Lactobacillus plantarum YML009 on Influenza virus H1N1

  • Irfan Ahmad Rather,
  • Kwang-Ho Choi,
  • Vivek K. Bajpai,
  • Yong-Ha Park

DOI
https://doi.org/10.3329/bjp.v10i2.23068
Journal volume & issue
Vol. 10, no. 2

Abstract

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The development of resistance against antiviral agents has augmented a threat to public health sector. Consequently there is an expanding demand for the development of unconventional antiviral agents that could efficiently replace the existent in-use drugs. The probiotic strains of lactic acid bacteria (LAB) have earned the status of being efficient, economical and safe “nutraceutical” in health care armamentarium. A total of 2272 LAB strains were screened against H1N1 virus. The isolate YML009 displayed a pronounced antiviral activity. Sequencing and biochemical assays identified the isolate as Lactoballius plantarum which, exhibited resistance to the damage caused by the acidic conditions such as gastric juice and 5% bile salt. The anti-H1N1 activity of the strain was confirmed by hemagglutination assay and was found to display enhanced efficacy in comparison to the commercially available antiviral drug. This is a primary report on anti-influenza activity of a bacterium L. plantarum YML009.

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