Immune-profiling of ZIKV-infected patients identifies a distinct function of plasmacytoid dendritic cells for immune cross-regulation

Xiaoming Sun; Stephane Hua; Ce Gao; Jane E. Blackmer; Zhengyu Ouyang; Kevin Ard; Andrea Ciaranello; Sigal Yawetz; Paul E. Sax; Eric S. Rosenberg; Mathias Lichterfeld; Xu G. Yu

doi:10.1038/s41467-020-16217-5

Nature Communications (May 2020)

Immune-profiling of ZIKV-infected patients identifies a distinct function of plasmacytoid dendritic cells for immune cross-regulation

Xiaoming Sun,
Stephane Hua,
Ce Gao,
Jane E. Blackmer,
Zhengyu Ouyang,
Kevin Ard,
Andrea Ciaranello,
Sigal Yawetz,
Paul E. Sax,
Eric S. Rosenberg,
Mathias Lichterfeld,
Xu G. Yu

Affiliations

Xiaoming Sun: Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital
Stephane Hua: Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital
Ce Gao: Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital
Jane E. Blackmer: Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital
Zhengyu Ouyang: Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital
Kevin Ard: Infectious Disease Division, Massachusetts General Hospital
Andrea Ciaranello: Infectious Disease Division, Massachusetts General Hospital
Sigal Yawetz: Infectious Disease Division, Brigham and Women’s Hospital
Paul E. Sax: Infectious Disease Division, Brigham and Women’s Hospital
Eric S. Rosenberg: Infectious Disease Division, Massachusetts General Hospital
Mathias Lichterfeld: Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital
Xu G. Yu: Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital

DOI: https://doi.org/10.1038/s41467-020-16217-5
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 13

Abstract

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Zika virus (ZIKV) poses a significant public health threat, but the immune landscape changes following ZIKV infection is still unclear. Here, the authors show, using flow cytometry and transcriptomic data, that ZIKV induces a multitude of immune responses, with plasmacytoid dendritic cells poised centrally to interact with other immune cell types.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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