Nature Communications (May 2022)
Targeted detection of cancer at the cellular level during biopsy by near-infrared confocal laser endomicroscopy
- Gregory T. Kennedy,
- Feredun S. Azari,
- Elizabeth Bernstein,
- Bilal Nadeem,
- Ashley Chang,
- Alix Segil,
- Sean Carlin,
- Neil T. Sullivan,
- Emmanuel Encarnado,
- Charuhas Desphande,
- Sumith Kularatne,
- Pravin Gagare,
- Mini Thomas,
- John C. Kucharczuk,
- Gaetan Christien,
- Francois Lacombe,
- Kaela Leonard,
- Philip S. Low,
- Aline Criton,
- Sunil Singhal
Affiliations
- Gregory T. Kennedy
- Department of Surgery, University of Pennsylvania School of Medicine
- Feredun S. Azari
- Department of Surgery, University of Pennsylvania School of Medicine
- Elizabeth Bernstein
- Department of Surgery, University of Pennsylvania School of Medicine
- Bilal Nadeem
- Department of Surgery, University of Pennsylvania School of Medicine
- Ashley Chang
- Department of Surgery, University of Pennsylvania School of Medicine
- Alix Segil
- Department of Surgery, University of Pennsylvania School of Medicine
- Sean Carlin
- Department of Radiology, University of Pennsylvania School of Medicine
- Neil T. Sullivan
- Department of Surgery, University of Pennsylvania School of Medicine
- Emmanuel Encarnado
- Department of Surgery, University of Pennsylvania School of Medicine
- Charuhas Desphande
- Department of Pathology, University of Pennsylvania School of Medicine
- Sumith Kularatne
- On Target Laboratories
- Pravin Gagare
- On Target Laboratories
- Mini Thomas
- On Target Laboratories
- John C. Kucharczuk
- Department of Surgery, University of Pennsylvania School of Medicine
- Gaetan Christien
- Mauna Kea Technologies
- Francois Lacombe
- Mauna Kea Technologies
- Kaela Leonard
- Mauna Kea Technologies
- Philip S. Low
- Department of Chemistry, Purdue University
- Aline Criton
- Mauna Kea Technologies
- Sunil Singhal
- Department of Surgery, University of Pennsylvania School of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-30265-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 9
Abstract
Radiography identifies suspicious lung nodules that are not always easy to diagnose via biopsy. Here, the authors utilize a fluorescent dye that targets the folate receptor and show using needle based endomicroscopy that it can be used to identify cancer cells during biopsy procedures
