World Allergy Organization Journal (Apr 2017)
International consensus (ICON) on: clinical consequences of mite hypersensitivity, a global problem
- Mario Sánchez-Borges,
- Enrique Fernandez-Caldas,
- Wayne R. Thomas,
- Martin D. Chapman,
- Bee Wah Lee,
- Luis Caraballo,
- Nathalie Acevedo,
- Fook Tim Chew,
- Ignacio J. Ansotegui,
- Leili Behrooz,
- Wanda Phipatanakul,
- Roy Gerth van Wijk,
- Demoly Pascal,
- Nelson Rosario,
- Motohiro Ebisawa,
- Mario Geller,
- Santiago Quirce,
- Susanne Vrtala,
- Rudolf Valenta,
- Markus Ollert,
- Giorgio Walter Canonica,
- Moises A. Calderón,
- Charles S. Barnes,
- Adnan Custovic,
- Suwat Benjaponpitak,
- Arnaldo Capriles-Hulett
Affiliations
- Mario Sánchez-Borges
- Allergy and Clinical Immunology Department, Centro Médico Docente La Trinidad
- Enrique Fernandez-Caldas
- Inmunotek S.L., Madrid, Spain and Division of Allergy and Immunology, University of South Florida College of Medicine
- Wayne R. Thomas
- Telethon Kids Institute, University of Western Australia
- Martin D. Chapman
- Indoor Biotechnologies
- Bee Wah Lee
- Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore
- Luis Caraballo
- Institute for Immunological Research, University of Cartagena
- Nathalie Acevedo
- University of Cartagena
- Fook Tim Chew
- Department of Biological Sciences, Allergy and Molecular Immunology Laboratory, Functional Genomics Laboratories, National University of Singapore
- Ignacio J. Ansotegui
- Department of Allergy and Immunology, Hospital Quirón Bizkaia
- Leili Behrooz
- Division of Immunology and Allergy, Boston Cshildren’s Hospital, Harvard Medical School
- Wanda Phipatanakul
- Division of Immunology and Allergy, Boston Cshildren’s Hospital, Harvard Medical School
- Roy Gerth van Wijk
- Department of Internal Medicine, Allergology, Erasmus MC
- Demoly Pascal
- Division of Allergy, Department of Pulmonology, University Hospital of Montpellier
- Nelson Rosario
- Federal University of Parana
- Motohiro Ebisawa
- Department of Allergy, Clinical Research Center for Allergology and Rheumatology, Sagamihara National Hospital
- Mario Geller
- Division of Medicine, Academy of Medicine of Rio de Janeiro
- Santiago Quirce
- Department of Allergy, Hospital La Paz Institute for Health Research and CIBER of Respiratory Diseases (CIBERES)
- Susanne Vrtala
- Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna
- Rudolf Valenta
- Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna
- Markus Ollert
- Department of Infection & Immunity, Laboratory of Immunogenetics and Allergology, Luxembourg Institute of Health
- Giorgio Walter Canonica
- Allergy & Respiratory Diseases Clinic, University of Genoa
- Moises A. Calderón
- Section of Allergy and Clinical Immunology, Imperial College London – NHLI
- Charles S. Barnes
- Division of Allergy/Immunology, Children’s Mercy Hospital
- Adnan Custovic
- Department of Paediatrics, Imperial College London
- Suwat Benjaponpitak
- Division of Pediatric Allergy/Immunology/Rheumatology, Department of Pediatrics, Ramathibodi Hospital, Mahidol University
- Arnaldo Capriles-Hulett
- Allergy and Clinical Immunology Department, Centro Médico Docente La Trinidad
- DOI
- https://doi.org/10.1186/s40413-017-0145-4
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 26
Abstract
Abstract Since mite allergens are the most relevant inducers of allergic diseases worldwide, resulting in significant morbidity and increased burden on health services, the International Collaboration in Asthma, Allergy and Immunology (iCAALL), formed by the American Academy of Allergy, Asthma and Immunology (AAAAI), the American College of Allergy, Asthma and Immunology (ACAAI), the European Academy of Allergy and Clinical Immunology (EAACI), and the World Allergy Organization (WAO), has proposed to issue an International Consensus (ICON) on the clinical consequences of mite hypersensitivity. The objectives of this document are to highlight aspects of mite biology that are clinically relevant, to update the current knowledge on mite allergens, routes of sensitization, the genetics of IgE responses to mites, the epidemiologic aspects of mite hypersensitivity, the clinical pictures induced by mites, the diagnosis, specific immunotherapeutic approaches, and prevention.
