Glycan recognition in globally dominant human rotaviruses

Liya Hu; Banumathi Sankaran; Daniel R. Laucirica; Ketki Patil; Wilhelm Salmen; Allan Chris M Ferreon; Phoebe S. Tsoi; Yi Lasanajak; David F. Smith; Sasirekha Ramani; Robert L. Atmar; Mary K. Estes; Josephine C. Ferreon; B. V. Venkataram Prasad

doi:10.1038/s41467-018-05098-4

Nature Communications (Jul 2018)

Glycan recognition in globally dominant human rotaviruses

Liya Hu,
Banumathi Sankaran,
Daniel R. Laucirica,
Ketki Patil,
Wilhelm Salmen,
Allan Chris M Ferreon,
Phoebe S. Tsoi,
Yi Lasanajak,
David F. Smith,
Sasirekha Ramani,
Robert L. Atmar,
Mary K. Estes,
Josephine C. Ferreon,
B. V. Venkataram Prasad

Affiliations

Liya Hu: Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine
Banumathi Sankaran: Molecular Biophysics and Integrated Bioimaging, Berkeley Center for Structural Biology, Lawrence Berkeley National Laboratory
Daniel R. Laucirica: Department of Molecular Virology and Microbiology, Baylor College of Medicine
Ketki Patil: Department of Molecular Virology and Microbiology, Baylor College of Medicine
Wilhelm Salmen: Department of Molecular Virology and Microbiology, Baylor College of Medicine
Allan Chris M Ferreon: Department of Pharmacology, Baylor College of Medicine
Phoebe S. Tsoi: Department of Pharmacology, Baylor College of Medicine
Yi Lasanajak: Department of Biochemistry and the Emory Comprehensive Glycomics Core, Emory University School of Medicine
David F. Smith: Department of Biochemistry and the Emory Comprehensive Glycomics Core, Emory University School of Medicine
Sasirekha Ramani: Department of Molecular Virology and Microbiology, Baylor College of Medicine
Robert L. Atmar: Department of Molecular Virology and Microbiology, Baylor College of Medicine
Mary K. Estes: Department of Molecular Virology and Microbiology, Baylor College of Medicine
Josephine C. Ferreon: Department of Pharmacology, Baylor College of Medicine
B. V. Venkataram Prasad: Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine

DOI: https://doi.org/10.1038/s41467-018-05098-4
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

Read online

Human rotaviruses (RV) bind to histo-blood group antigens (HBGA) for attachment, but how different viral genotypes interact with HBGA isn’t known. Here, Hu et al. report crystal structures of a prevalent and a neonate-specific RV in complex with HBGA and provide insights into glycan recognition and age-restricted tropism of RVs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal