Thermodynamic control of −1 programmed ribosomal frameshifting

Lars V. Bock; Neva Caliskan; Natalia Korniy; Frank Peske; Marina V. Rodnina; Helmut Grubmüller

doi:10.1038/s41467-019-12648-x

Nature Communications (Oct 2019)

Thermodynamic control of −1 programmed ribosomal frameshifting

Lars V. Bock,
Neva Caliskan,
Natalia Korniy,
Frank Peske,
Marina V. Rodnina,
Helmut Grubmüller

Affiliations

Lars V. Bock: Theoretical and Computational Biophysics, Max Planck Institute for Biophysical Chemistry
Neva Caliskan: Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI)
Natalia Korniy: Department of Physical Biochemistry, Max Planck Institute for Biophysical Chemistry
Frank Peske: Department of Physical Biochemistry, Max Planck Institute for Biophysical Chemistry
Marina V. Rodnina: Department of Physical Biochemistry, Max Planck Institute for Biophysical Chemistry
Helmut Grubmüller: Theoretical and Computational Biophysics, Max Planck Institute for Biophysical Chemistry

DOI: https://doi.org/10.1038/s41467-019-12648-x
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 11

Abstract

Read online

Programmed ribosomal frameshifting (PRF) is an alternative translation strategy that causes controlled slippage of the ribosome along the mRNA, changing the sequence of the synthesized protein. Here the authors provide a thermodynamic framework that explains how mRNA sequence determines the efficiency of frameshifting.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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