Biodegradable Synthetic Organelles Demonstrate ROS Shielding in Human-Complex-I-Deficient Fibroblasts

• Lisanne M. P. E. van Oppen,
• Loai K. E. A. Abdelmohsen,
• Sjenet E. van Emst-de Vries,
• Pascal L. W. Welzen,
• Daniela A. Wilson,
• Jan A. M. Smeitink,
• Werner J. H. Koopman,
• Roland Brock,
• Peter H. G. M. Willems,
• David S. Williams,
• Jan C.M. van Hest

Affiliations

Lisanne M. P. E. van Oppen

Department of Biochemistry, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands

Loai K. E. A. Abdelmohsen

Department of Biomedical Engineering & Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, Eindhoven, The Netherlands

Sjenet E. van Emst-de Vries

Department of Biochemistry, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands

Pascal L. W. Welzen

Department of Biomedical Engineering & Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, Eindhoven, The Netherlands

Daniela A. Wilson

Institute for Molecules and Materials (IMM), Radboud University, Nijmegen, The Netherlands

Jan A. M. Smeitink

Department of Pediatrics, Radboud Centre for Mitochondrial Disease, Radboud University Medical Center, Nijmegen, The Netherlands

Werner J. H. Koopman

Department of Biochemistry, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands

Roland Brock

Department of Biochemistry, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands

Peter H. G. M. Willems

Department of Biochemistry, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands

David S. Williams

Department of Chemistry, Swansea University, Swansea, United Kingdom

Jan C.M. van Hest

Department of Biomedical Engineering & Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, Eindhoven, The Netherlands