Türk Kardiyoloji Derneği Arşivi (May 2018)

The relationship between low thiol levels and major adverse cardiovascular events after primary percutaneous coronary intervention in patients with STEMI

  • Oğuz Akkuş,
  • Mustafa Topuz,
  • Hasan Koca,
  • Hazar Harbalioğlu,
  • Onur Kaypaklı,
  • Mehmet Kaplan,
  • Ömer Şen,
  • Atilla Bulut,
  • Hakim Çelik,
  • Özcan Erel,
  • Mustafa Gür

DOI
https://doi.org/10.5543/tkda.2018.82668
Journal volume & issue
Vol. 46, no. 4
pp. 248 – 259

Abstract

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Objective: The aim of this study was to investigate whether low thiol levels are associated with peri-procedural factors during primary percutaneous coronary intervention (pPCI) upon admission with ST-segment elevation myocardial infarction (STEMI), and the prognostic value at 6-month follow-up. Methods: A total of 241 consecutive acute STEMI patients who underwent pPCI and a control group of 67 individuals with a normal coronary angiography were enrolled in the study. Results: While age, contrast-induced nephropathy, N-terminal prohormone of brain natriuretic peptide (NT-proBNP), stent length, and creatinine were related to native thiol, NT-proBNP, contrast-induced nephropathy, and creatinine were related to total thiol. NT-proBNP was also related to the disulphide level. The left ventricular ejection fraction (LVEF) and the levels of native thiol, total thiol, low-density lipoprotein, and serum albumin were found to be independent predictors of major adverse cardiovascular events (MACEs) during 6 months of follow-up. Conclusion: Initial lower native thiol, total thiol, LVEF, LDL, and serum albumin may be used to identify patients with an increased long-term risk of unfavorable cardiac events in case of STEMI.

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