A machine learning method for predicting disease-associated microRNA connections using network internal topology data

Abstract

Recent studies have shown that aberrations or mutations of microRNAs (miRNA) can cause various diseases. Therefore, identifying disease-associated microRNAs can aid in diagnosing and treating related disorders. However, getting precise correlations through biological research is expensive and time-consuming. This research suggests a machine learning method (HNDLM) based on network internal topology data to anticipate disease-miRNA connections. HNDLM applies the recently described network embedding technique to biological networks rather than creating similar ones. According to the experimental findings, HNDLM performs better in terms of accuracy and Area Under the ROC Curve (AUC) value when compared to the traditional algorithms MIDPE, MIDP, WBSMDA, RLSMDA, Collective Prediction based on Transductive Learning (CPTL), and Human Disease-related MiRNA Prediction (HDMP). The top 30 potential miRNAs suggested by HNDLM can also be verified by earlier research in the case study. HNDLM can identify probable disease-miRNA correlations, which will aid in the investigation of illness path physiology and advance the field of bioinformatics.

Keywords

• Machine learning
• Bioinformatics
• MicroRNAs
• Correlations
• Link prediction