Synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways

David A. Ruhl; Ewa Bomba-Warczak; Emma T. Watson; Mazdak M. Bradberry; Tabitha A. Peterson; Trina Basu; Alyssa Frelka; Chantell S. Evans; Joseph S. Briguglio; Tamara Basta; Michael H. B. Stowell; Jeffrey N. Savas; Avtar Roopra; Robert A. Pearce; Robert C. Piper; Edwin R. Chapman

doi:10.1038/s41467-019-11459-4

Nature Communications (Aug 2019)

Synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways

David A. Ruhl,
Ewa Bomba-Warczak,
Emma T. Watson,
Mazdak M. Bradberry,
Tabitha A. Peterson,
Trina Basu,
Alyssa Frelka,
Chantell S. Evans,
Joseph S. Briguglio,
Tamara Basta,
Michael H. B. Stowell,
Jeffrey N. Savas,
Avtar Roopra,
Robert A. Pearce,
Robert C. Piper,
Edwin R. Chapman

Affiliations

David A. Ruhl: Department of Neuroscience, University of Wisconsin
Ewa Bomba-Warczak: Department of Neurology, Feinberg School of Medicine, Northwestern University
Emma T. Watson: Department of Neuroscience, University of Wisconsin
Mazdak M. Bradberry: Department of Neuroscience, University of Wisconsin
Tabitha A. Peterson: Department of Molecular Physiology and Biophysics, University of Iowa
Trina Basu: Department of Neuroscience, University of Wisconsin
Alyssa Frelka: Department of Anesthesiology, University of Wisconsin
Chantell S. Evans: Department of Physiology, Perelman School of Medicine, University of Pennsylvania
Joseph S. Briguglio: Department of Neuroscience, University of Wisconsin
Tamara Basta: Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder
Michael H. B. Stowell: Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder
Jeffrey N. Savas: Department of Neurology, Feinberg School of Medicine, Northwestern University
Avtar Roopra: Department of Neuroscience, University of Wisconsin
Robert A. Pearce: Department of Anesthesiology, University of Wisconsin
Robert C. Piper: Department of Molecular Physiology and Biophysics, University of Iowa
Edwin R. Chapman: Department of Neuroscience, University of Wisconsin

DOI: https://doi.org/10.1038/s41467-019-11459-4
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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The functional role of synaptotagmin-17 (syt-17) has remained unanswered. In this study, authors demonstrate that syt-17 exists in two distinct pools in hippocampal neurons (Golgi complex and early endosomes), where it served two completely independent functions: controlling neurite outgrowth and synaptic physiology

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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