Transient microglial absence assists postmigratory cortical neurons in proper differentiation

Yuki Hattori; Yu Naito; Yoji Tsugawa; Shigenori Nonaka; Hiroaki Wake; Takashi Nagasawa; Ayano Kawaguchi; Takaki Miyata

doi:10.1038/s41467-020-15409-3

Nature Communications (Apr 2020)

Transient microglial absence assists postmigratory cortical neurons in proper differentiation

Yuki Hattori,
Yu Naito,
Yoji Tsugawa,
Shigenori Nonaka,
Hiroaki Wake,
Takashi Nagasawa,
Ayano Kawaguchi,
Takaki Miyata

Affiliations

Yuki Hattori: Department of Anatomy and Cell Biology, Graduate School of Medicine, Nagoya University
Yu Naito: Department of Anatomy and Cell Biology, Graduate School of Medicine, Nagoya University
Yoji Tsugawa: Department of Aging Intervention, National Center for Geriatrics and Gerontology
Shigenori Nonaka: Spatiotemporal Regulations Group, Exploratory Research Center on Life and Living Systems
Hiroaki Wake: Division of Homeostatic Development, National Institute for Physiological Sciences
Takashi Nagasawa: Laboratory of Stem Cell Biology and Developmental Immunology, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University
Ayano Kawaguchi: Department of Anatomy and Cell Biology, Graduate School of Medicine, Nagoya University
Takaki Miyata: Department of Anatomy and Cell Biology, Graduate School of Medicine, Nagoya University

DOI: https://doi.org/10.1038/s41467-020-15409-3
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 18

Abstract

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Microglia temporarily disappear from the cortical plate in the midembryonic stage. This study demonstrated that microglial transient absence from the cortical plate is required for postmigratory neurons to appropriately fine-tune the expression of molecules needed for their proper differentiation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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