Evaluation of Chromosomal Anomalies and Polymorphisms in Primer Infertility, Azospermia and Habitual Abortion Patient Groups

Abstract

INTRODUCTION: Infertility is defined as the inability to achieve pregnancy despite regular sexual intercourse for one year, although a couple with fertility does not use contraception. In our study, infertile individuals were examined under three main groups. These groups are azoospermia, habitual abortion and primer infertility groups. Chromosomal anomalies and polymorphisms observed in groups were investigated retrospectively. METHODS: Between January 2017 and January 2018, 1381 individuals aged 17-54 years who were referred for azoospermia, recurrent pregnancy loss and primary infertility were included in the study and the results of chromosome analysis were examined RESULTS: A chromosome anomaly or polymorphism was observed in 9.8% of the cases. The rate of polymorphism was 5.65% in all patient groups. The chromosomal anomaly rate in all cases was 4.2%. DISCUSSION AND CONCLUSION: Chromosomal polymorphism and anomaly differences among the groups were discussed in data of our country and world literatures. We emphasized that although the relevant patient groups, especially the habitual abortion patient group, have indications for chromosome analysis, we should first exclude the more frequently observed etiologic factors.

Keywords

• azospermia
• habitual abortion
• infertility
• chromosomal polymorphism
• chromosome anomaly