The Association of Serum Adiponectin Level and Various Biochemical and Metabolic Factors in Patients under Hemodialysis

Abstract

Background: Serum adiponectin (ADPN), an adipocyte-produced hormone, has a higher level in patients with uremia with or without diabetes. Plasma ADPN levels are direct predictor of cardiovascular outcomes among patients with end stage renal disease (ESRD). Also, Studies showed that level of adiponectin reflects death. Methods: Seventy-three under-hemodialysis patients without diabetes were selected. Fasting blood sample of all patients was caught to determine ADPN level and other parameters. Weight, body mass index, waist and abdomen were measured, too. To assess the relationship of ADPN level with other parameters, Pearson test was used. Findings: There was significant negative association of ADPN level with weight (P < 0.001), body mass index (P < 0.001), waist (P < 0.05) and abdomen (P < 0.01) circumferences and serum triglyceride level (P < 0.01). Conclusion: Our results demonstrated that serum ADPN level in without-diabetes patients under hemodialysis show malnutrition, wasting and lower muscle and fat tissue. The findings need further evaluation to precisely find the impact of ADPN on mortality and morbidity of under-hemodialysis patients.

Keywords

• Adiponectin
• End-stage renal disease
• Renal function
• Hemodialysis