Self-Healing Thiolated Pillar[5]arene Films Containing Moxifloxacin Suppress the Development of Bacterial Biofilms
Dmitriy N. Shurpik,
Yulia I. Aleksandrova,
Olga A. Mostovaya,
Viktoriya A. Nazmutdinova,
Regina E. Tazieva,
Fadis F. Murzakhanov,
Marat R. Gafurov,
Pavel V. Zelenikhin,
Evgenia V. Subakaeva,
Evgenia A. Sokolova,
Alexander V. Gerasimov,
Vadim V. Gorodov,
Daut R. Islamov,
Peter J. Cragg,
Ivan I. Stoikov
Affiliations
Dmitriy N. Shurpik
A.M.Butlerov Chemical Institute, Kazan Federal University, Kremlevskaya, 18, 420008 Kazan, Russia
Yulia I. Aleksandrova
A.M.Butlerov Chemical Institute, Kazan Federal University, Kremlevskaya, 18, 420008 Kazan, Russia
Olga A. Mostovaya
A.M.Butlerov Chemical Institute, Kazan Federal University, Kremlevskaya, 18, 420008 Kazan, Russia
Viktoriya A. Nazmutdinova
A.M.Butlerov Chemical Institute, Kazan Federal University, Kremlevskaya, 18, 420008 Kazan, Russia
Regina E. Tazieva
A.M.Butlerov Chemical Institute, Kazan Federal University, Kremlevskaya, 18, 420008 Kazan, Russia
Fadis F. Murzakhanov
Institute of Physics, Kazan Federal University, Kremlevskaya, 18, 420008 Kazan, Russia
Marat R. Gafurov
Institute of Physics, Kazan Federal University, Kremlevskaya, 18, 420008 Kazan, Russia
Pavel V. Zelenikhin
Institute of Fundamental Medicine and Biology, Kazan Federal University, Kremlevskaya, 18, 420008 Kazan, Russia
Evgenia V. Subakaeva
Institute of Fundamental Medicine and Biology, Kazan Federal University, Kremlevskaya, 18, 420008 Kazan, Russia
Evgenia A. Sokolova
Institute of Fundamental Medicine and Biology, Kazan Federal University, Kremlevskaya, 18, 420008 Kazan, Russia
Alexander V. Gerasimov
A.M.Butlerov Chemical Institute, Kazan Federal University, Kremlevskaya, 18, 420008 Kazan, Russia
Vadim V. Gorodov
Enikolopov Institute of Synthetic Polymeric Materials, Russian Academy of Sciences (ISPM RAS), Profsoyuznaya, 70, 117393 Moscow, Russia
Daut R. Islamov
Laboratory for Structural Analysis of Biomacromolecules, Kazan Scientific Center of Russian Academy of Sciences, Lobachevskogo, 2/31, 420111 Kazan, Russia
Peter J. Cragg
School of Applied Sciences, University of Brighton, Huxley Building, Brighton BN2 4GJ, UK
Ivan I. Stoikov
A.M.Butlerov Chemical Institute, Kazan Federal University, Kremlevskaya, 18, 420008 Kazan, Russia
Polymer self-healing films containing fragments of pillar[5]arene were obtained for the first time using thiol/disulfide redox cross-linking. These films were characterized by thermogravimetric analysis and differential scanning calorimetry, FTIR spectroscopy, and electron microscopy. The films demonstrated the ability to self-heal through the action of atmospheric oxygen. Using UV–vis, 2D 1H-1H NOESY, and DOSY NMR spectroscopy, the pillar[5]arene was shown to form complexes with the antimicrobial drug moxifloxacin in a 2:1 composition (logK11 = 2.14 and logK12 = 6.20). Films containing moxifloxacin effectively reduced Staphylococcus aureus and Klebsiella pneumoniae biofilms formation on adhesive surfaces.
