Nature Communications (Jan 2021)
CTLA-4 expression by B-1a B cells is essential for immune tolerance
- Yang Yang,
- Xiao Li,
- Zhihai Ma,
- Chunlin Wang,
- Qunying Yang,
- Miranda Byrne-Steele,
- Rongjian Hong,
- Qing Min,
- Gao Zhou,
- Yong Cheng,
- Guang Qin,
- Justin V. Youngyunpipatkul,
- James B. Wing,
- Shimon Sakaguchi,
- Christian Toonstra,
- Lai-Xi Wang,
- Jose G. Vilches-Moure,
- Denong Wang,
- Michael P. Snyder,
- Ji-Yang Wang,
- Jian Han,
- Leonore A. Herzenberg
Affiliations
- Yang Yang
- Department of Genetics, Stanford University School of Medicine
- Xiao Li
- The Center for RNA Science and Therapeutics, Case Western Reserve University
- Zhihai Ma
- Department of Genetics, Stanford University School of Medicine
- Chunlin Wang
- iRepertoire Inc
- Qunying Yang
- iRepertoire Inc
- Miranda Byrne-Steele
- iRepertoire Inc
- Rongjian Hong
- Department of Immunology, School of Basic Medical Sciences, Fudan University
- Qing Min
- Department of Immunology, School of Basic Medical Sciences, Fudan University
- Gao Zhou
- The Center for RNA Science and Therapeutics, Case Western Reserve University
- Yong Cheng
- St. Jude Children’s Research Hospital
- Guang Qin
- Department of Genetics, Stanford University School of Medicine
- Justin V. Youngyunpipatkul
- Department of Genetics, Stanford University School of Medicine
- James B. Wing
- Laboratory of Human Immunology (Single Cell Immunology), World Premier International Immunology Frontier Research Center, Osaka University
- Shimon Sakaguchi
- Laboratory of Experimental Immunology, World Premier International Immunology Frontier Research Center, Osaka University
- Christian Toonstra
- Department of Chemistry and Biochemistry, University of Maryland
- Lai-Xi Wang
- Department of Chemistry and Biochemistry, University of Maryland
- Jose G. Vilches-Moure
- Department of Comparative Medicine, Stanford University School of Medicine
- Denong Wang
- Tumor Glycomics Laboratory, SRI International Biosciences Division
- Michael P. Snyder
- Department of Genetics, Stanford University School of Medicine
- Ji-Yang Wang
- Department of Immunology, School of Basic Medical Sciences, Fudan University
- Jian Han
- iRepertoire Inc
- Leonore A. Herzenberg
- Department of Genetics, Stanford University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-020-20874-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
CTLA-4 is an important co-inhibitory receptor for T cells. Here, the authors show that CTLA-4 also has a function on B-1a cells, as conditional deletion results in activation of these cells and knockout mice develop an autoimmune profile.
