The research progress on the mechanism of icariin acceleratingfracture healing

Abstract

In recent years, international and domestic academics have made a series of studies on themechanism of icariin which is the main effective component of Herba Epimedii, to accelerate fracture healing.The current research results show that the mechanism of icariin accelerating fracture healing is to promote themigration and homing of BMSCs and ASCs by activating Wnts, BMP, MAPK, ER and other related signalpathways, so as to carry out osteogenic differentiation into osteoblasts. At the same time, it can promotethe maturation and mineralization of osteoblasts to form callus, and inhibit the bone resorption activity ofosteoclasts. This article reviews the mechanism of icariin in accelerating fracture healing from the aspectsof its effects on related cells and vascular remodeling, so as to provide reference for the follow-up research.

Keywords

• herba epimedii
• icariin
• fracture healing
• cell
• signaling pathway