The transcriptional regulator ZNF398 mediates pluripotency and epithelial character downstream of TGF-beta in human PSCs

Irene Zorzan; Marco Pellegrini; Mattia Arboit; Danny Incarnato; Mara Maldotti; Mattia Forcato; Guidantonio Malagoli Tagliazucchi; Elena Carbognin; Marco Montagner; Salvatore Oliviero; Graziano Martello

doi:10.1038/s41467-020-16205-9

Nature Communications (May 2020)

The transcriptional regulator ZNF398 mediates pluripotency and epithelial character downstream of TGF-beta in human PSCs

Irene Zorzan,
Marco Pellegrini,
Mattia Arboit,
Danny Incarnato,
Mara Maldotti,
Mattia Forcato,
Guidantonio Malagoli Tagliazucchi,
Elena Carbognin,
Marco Montagner,
Salvatore Oliviero,
Graziano Martello

Affiliations

Irene Zorzan: Department of Molecular Medicine, Medical School, University of Padua
Marco Pellegrini: Department of Molecular Medicine, Medical School, University of Padua
Mattia Arboit: Department of Molecular Medicine, Medical School, University of Padua
Danny Incarnato: Department of Life Sciences and Systems Biology and Molecular Biotechnology Center (MCB), University of Turin
Mara Maldotti: Department of Life Sciences and Systems Biology and Molecular Biotechnology Center (MCB), University of Turin
Mattia Forcato: Department of Life Sciences, University of Modena and Reggio Emilia
Guidantonio Malagoli Tagliazucchi: Department of Life Sciences, University of Modena and Reggio Emilia
Elena Carbognin: Department of Molecular Medicine, Medical School, University of Padua
Marco Montagner: Department of Molecular Medicine, Medical School, University of Padua
Salvatore Oliviero: Department of Life Sciences and Systems Biology and Molecular Biotechnology Center (MCB), University of Turin
Graziano Martello: Department of Molecular Medicine, Medical School, University of Padua

DOI: https://doi.org/10.1038/s41467-020-16205-9
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 16

Abstract

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The downstream pathway regulating how TGF-beta affects pluripotency of human PSCs is unclear. Here, the authors find that transcription factor ZNF398 binds active promoters/enhancers together with the histone acetyltransferase EP300 and SMAD3, enabling expression of pluripotency and epithelial genes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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