International Journal of Hematology-Oncology and Stem Cell Research (Apr 2020)

Treatment of Acute Lymphoid Leukemia Refractory to Classic First-Line and Rescue Protocols

  • Flávia Tobaldini Russo,
  • Maria Cristina Martins de Almeida Macedo,
  • Pedro Amoedo Fernandes,
  • Larissa Yukari Okada,
  • Lucas Augusto Monetta da Silva,
  • Camila Menin Simões,
  • Jamilla Neves Cavalcante,
  • Aline de Almeida Simões,
  • Manuella de Souza Sampaio Almeida,
  • Maricy Almeida Viol Ferreira Lopes,
  • Roberto Luiz da Silva

DOI
https://doi.org/10.18502/ijhoscr.v14i2.2676
Journal volume & issue
Vol. 14, no. 2

Abstract

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Acute Lymphoblastic Leukemia is a very aggressive malignant disorder of lymphoid cells in adults, with recurrence (30 to 60% of the cases) after the initial treatment. Until this moment, there is no gold standard therapy for the treatment of adult patients with acute relapsed/refractory lymphoblastic leukemia. In this case report, we describe two cases of relapsed leukemia: one of lymphocytic leukemia B and one of trilineage leukemia, which presented a satisfactory response to treatment with Bortezomib associated with Vincristine, Dexamethasone, and Bendamustine.

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