Molecules
(Nov 2015)
Two New Cyototoxic Cardenolides from the Whole Plants of Adonis multiflora Nishikawa & Koki Ito
Jae-Woo Jung,
Nam-In Baek,
Jeon Hwang-Bo,
Seung-Su Lee,
Ji-Hae Park,
Kyeong-Hwa Seo,
Jung-Hwa Kwon,
Eun-Ji Oh,
Dae-Young Lee,
In-Sik Chung,
Myun-Ho Bang
Affiliations
Jae-Woo Jung
Graduate School of Biotechnology and Department of Oriental Medicine Biotechnology, Kyung Hee University, Yongin 446-701, Korea
Nam-In Baek
Graduate School of Biotechnology and Department of Oriental Medicine Biotechnology, Kyung Hee University, Yongin 446-701, Korea
Jeon Hwang-Bo
Graduate School of Biotechnology and Department of Genetic Engineering, Kyung Hee University, Yongin 446-701, Korea
Seung-Su Lee
Graduate School of Biotechnology and Department of Oriental Medicine Biotechnology, Kyung Hee University, Yongin 446-701, Korea
Ji-Hae Park
Graduate School of Biotechnology and Department of Oriental Medicine Biotechnology, Kyung Hee University, Yongin 446-701, Korea
Kyeong-Hwa Seo
Graduate School of Biotechnology and Department of Oriental Medicine Biotechnology, Kyung Hee University, Yongin 446-701, Korea
Jung-Hwa Kwon
Graduate School of Biotechnology and Department of Oriental Medicine Biotechnology, Kyung Hee University, Yongin 446-701, Korea
Eun-Ji Oh
Graduate School of Biotechnology and Department of Oriental Medicine Biotechnology, Kyung Hee University, Yongin 446-701, Korea
Dae-Young Lee
Department of Herbal Crop Research, National Institute of Horicultural and Herbal Science, RDA, Eumseong 369-873, Korea
In-Sik Chung
Graduate School of Biotechnology and Department of Genetic Engineering, Kyung Hee University, Yongin 446-701, Korea
Myun-Ho Bang
Graduate School of Biotechnology and Department of Oriental Medicine Biotechnology, Kyung Hee University, Yongin 446-701, Korea
DOI
https://doi.org/10.3390/molecules201119722
Journal volume & issue
Vol. 20,
no. 11
Abstract
Read online
A phytochemical investigation of the whole plants of Adonis multiflora Nishikawa & Koki Ito. resulted in the isolation and identification of two new cardenolides—adonioside A (1) and adonioside B (6)—as well as four known cardenolides: tupichinolide (2) oleandrine (3), cryptostigmin II (4), and cymarin (5). Their structures were elucidated on the basis of NMR, MS, and IR spectroscopic analyses. Compounds 1, 2, 5, and 6 showed significant cytotoxicity against six human cancer cell lines (HCT-116, HepG2, HeLa, SK-OV-3, and SK-MEL-5, and SK-BR-3).
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