Nature Communications (Jan 2021)

Biomimetic selenocystine based dynamic combinatorial chemistry for thiol-disulfide exchange

  • Andrea Canal-Martín,
  • Ruth Pérez-Fernández

DOI
https://doi.org/10.1038/s41467-020-20415-6
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

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Thiol-disulfide exchange is an extensively used reversible reaction in dynamic combinatorial chemistry, but usually requires long time to reach equilibrium. Here, the authors employ selenocystine as a catalyst of thiol-disulfide exchange at low temperatures and basic pH, and show that it can promote disulfide bond formation during folding of a scrambled RNase A.