Nature Communications (Oct 2018)

Molecular architecture and regulation of BCL10-MALT1 filaments

  • Florian Schlauderer,
  • Thomas Seeholzer,
  • Ambroise Desfosses,
  • Torben Gehring,
  • Mike Strauss,
  • Karl-Peter Hopfner,
  • Irina Gutsche,
  • Daniel Krappmann,
  • Katja Lammens

DOI
https://doi.org/10.1038/s41467-018-06573-8
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 12

Abstract

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The BCL10-MALT1 complex is a central signaling hub in lymphocytes and linked to various human immune pathologies. Here the authors present the cryo-EM structure of the BCL10-MALT1 filament core and verify the identified BCL10/MALT1 interface with mutagenesis studies.