EFFECTS OF SOLVENT, BASE, AND TEMPERATURE IN THE OPTIMISATION OF A NEW CATALYTIC SYSTEM FOR SONOGASHIRA CROSS-COUPLING USING NCP PINCER PALLADACYCLE

Abstract

The optimisation of a new catalyst system using NCP pincer palladacycle 1 was investigated using the experimental design technique. NCP pincer palladacycle 1 was previously investigated in Suzuki-Miyaura and Heck-Mizoroki cross-couplings and found to be a highly efficient catalyst precursor. In this study, the effects of the type of base (K3PO4 or DABCO), solvent (DMF or dioxane) and reaction temperature (130 or 150 ºC) in the second step on the reactional yield in Sonogashira cross-coupling were assessed using the two-factor design. The results showed that temperature is statistically significant in relation to the reaction yield.

Keywords

• Sonogashira cross-coupling
• Dupont’s catalyst
• experimental design