ANTIOXIDANTS AS POTENTIAL BIOMARKERS OF NONALCOHOLIC FATTY LIVER DISEASE STAGES

Abstract

Nonalcoholic fatty liver disease is a complex and multifactorial pathology associated with multiple epigenetic, genetic and environmental factors, and its pathogenesis is still not fully understood. Nonalcoholic fatty liver disease begins with simple steatosis and progresses to nonalcoholic steatohepatitis, which is characterized by signs of oxidative stress, increased lipid peroxidation activity, inflammation, fibrosis, and apoptosis. Antioxidant deficiency is important in the pathogenesis of nonalcoholic fatty liver disease, as it is they that cause the transition of steatosis to steatohepatitis in nonalcoholic fatty liver disease. Markers of antioxidant defense are used to assess disease progression and pathologic state. This article reviews several key biomarkers of antioxidant defense that can be investigated in clinical practice. Determination of these biomarkers in nonalcoholic fatty liver disease can be used for diagnostic purposes.

Keywords

• печень, антиоксиданты, биомаркеры, антиоксидантная защита, нажбп, глутатион.