Nature Communications (May 2016)
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms
- Karsten Boldt,
- Jeroen van Reeuwijk,
- Qianhao Lu,
- Konstantinos Koutroumpas,
- Thanh-Minh T. Nguyen,
- Yves Texier,
- Sylvia E. C. van Beersum,
- Nicola Horn,
- Jason R. Willer,
- Dorus A. Mans,
- Gerard Dougherty,
- Ideke J. C. Lamers,
- Karlien L. M. Coene,
- Heleen H. Arts,
- Matthew J. Betts,
- Tina Beyer,
- Emine Bolat,
- Christian Johannes Gloeckner,
- Khatera Haidari,
- Lisette Hetterschijt,
- Daniela Iaconis,
- Dagan Jenkins,
- Franziska Klose,
- Barbara Knapp,
- Brooke Latour,
- Stef J. F. Letteboer,
- Carlo L. Marcelis,
- Dragana Mitic,
- Manuela Morleo,
- Machteld M. Oud,
- Moniek Riemersma,
- Susan Rix,
- Paulien A. Terhal,
- Grischa Toedt,
- Teunis J. P. van Dam,
- Erik de Vrieze,
- Yasmin Wissinger,
- Ka Man Wu,
- Gordana Apic,
- Philip L. Beales,
- Oliver E. Blacque,
- Toby J. Gibson,
- Martijn A. Huynen,
- Nicholas Katsanis,
- Hannie Kremer,
- Heymut Omran,
- Erwin van Wijk,
- Uwe Wolfrum,
- François Kepes,
- Erica E. Davis,
- Brunella Franco,
- Rachel H. Giles,
- Marius Ueffing,
- Robert B. Russell,
- Ronald Roepman,
- UK10K Rare Diseases Group
Affiliations
- Karsten Boldt
- Medical Proteome Center, Institute for Ophthalmic Research, University of Tuebingen
- Jeroen van Reeuwijk
- Department of Human Genetics and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- Qianhao Lu
- Biochemie Zentrum Heidelberg (BZH), University of Heidelberg
- Konstantinos Koutroumpas
- Institute of Systems and Synthetic Biology, Genopole, CNRS, Université d’Evry
- Thanh-Minh T. Nguyen
- Department of Human Genetics and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- Yves Texier
- Medical Proteome Center, Institute for Ophthalmic Research, University of Tuebingen
- Sylvia E. C. van Beersum
- Department of Human Genetics and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- Nicola Horn
- Medical Proteome Center, Institute for Ophthalmic Research, University of Tuebingen
- Jason R. Willer
- Center for Human Disease Modeling, Duke University
- Dorus A. Mans
- Department of Human Genetics and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- Gerard Dougherty
- Department of General Pediatrics, University Children's Hospital Muenster
- Ideke J. C. Lamers
- Department of Human Genetics and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- Karlien L. M. Coene
- Department of Human Genetics and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- Heleen H. Arts
- Department of Human Genetics and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- Matthew J. Betts
- Biochemie Zentrum Heidelberg (BZH), University of Heidelberg
- Tina Beyer
- Medical Proteome Center, Institute for Ophthalmic Research, University of Tuebingen
- Emine Bolat
- Department of Human Genetics and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- Christian Johannes Gloeckner
- German Center for Neurodegenerative Diseases (DZNE) within the Helmholz Association
- Khatera Haidari
- Department of Nephrology and Hypertension, Regenerative Medicine Center, University Medical Center Utrecht
- Lisette Hetterschijt
- Department of Otorhinolaryngology and Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center
- Daniela Iaconis
- Telethon Institute of Genetics and Medicine
- Dagan Jenkins
- Molecular Medicine Unit and Birth Defects Research Centre, UCL Institute of Child Health
- Franziska Klose
- Medical Proteome Center, Institute for Ophthalmic Research, University of Tuebingen
- Barbara Knapp
- Cell and Matrix Biology, Inst. of Zoology, Johannes Gutenberg University of Mainz
- Brooke Latour
- Department of Human Genetics and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- Stef J. F. Letteboer
- Department of Human Genetics and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- Carlo L. Marcelis
- Department of Human Genetics and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- Dragana Mitic
- Cambridge Cell Networks Ltd
- Manuela Morleo
- Telethon Institute of Genetics and Medicine
- Machteld M. Oud
- Department of Human Genetics and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- Moniek Riemersma
- Department of Human Genetics and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- Susan Rix
- Molecular Medicine Unit and Birth Defects Research Centre, UCL Institute of Child Health
- Paulien A. Terhal
- Department of Genetics, University Medical Center Utrecht
- Grischa Toedt
- Structural and Computational Biology Unit, European Molecular Biology Laboratory
- Teunis J. P. van Dam
- Centre for Molecular and Biomolecular Informatics and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- Erik de Vrieze
- Department of Otorhinolaryngology and Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center
- Yasmin Wissinger
- Medical Proteome Center, Institute for Ophthalmic Research, University of Tuebingen
- Ka Man Wu
- Department of Human Genetics and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- Gordana Apic
- Cambridge Cell Networks Ltd
- Philip L. Beales
- Molecular Medicine Unit and Birth Defects Research Centre, UCL Institute of Child Health
- Oliver E. Blacque
- School of Biomolecular & Biomed Science, Conway Institute, University College Dublin
- Toby J. Gibson
- Structural and Computational Biology Unit, European Molecular Biology Laboratory
- Martijn A. Huynen
- Centre for Molecular and Biomolecular Informatics and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- Nicholas Katsanis
- Center for Human Disease Modeling, Duke University
- Hannie Kremer
- Department of Otorhinolaryngology and Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center
- Heymut Omran
- Department of General Pediatrics, University Children's Hospital Muenster
- Erwin van Wijk
- Department of Otorhinolaryngology and Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center
- Uwe Wolfrum
- Cell and Matrix Biology, Inst. of Zoology, Johannes Gutenberg University of Mainz
- François Kepes
- Institute of Systems and Synthetic Biology, Genopole, CNRS, Université d’Evry
- Erica E. Davis
- Center for Human Disease Modeling, Duke University
- Brunella Franco
- Telethon Institute of Genetics and Medicine
- Rachel H. Giles
- Department of Nephrology and Hypertension, Regenerative Medicine Center, University Medical Center Utrecht
- Marius Ueffing
- Medical Proteome Center, Institute for Ophthalmic Research, University of Tuebingen
- Robert B. Russell
- Biochemie Zentrum Heidelberg (BZH), University of Heidelberg
- Ronald Roepman
- Department of Human Genetics and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- UK10K Rare Diseases Group
- DOI
- https://doi.org/10.1038/ncomms11491
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 13
Abstract
Mutations in proteins that localize to primary cilia cause devastating diseases, yet the primary cilium is a poorly understood organelle. Here the authors use interaction proteomics to identify a network of human ciliary proteins that provides new insights into several biological processes and diseases.
