Frontiers in Cardiovascular Medicine (Nov 2021)
Associations of Serum Uromodulin and Its Genetic Variants With Blood Pressure and Hypertension in Chinese Adults
- Yang Wang,
- Yang Wang,
- Ming-Fei Du,
- Shi Yao,
- Ting Zou,
- Xiao-Yu Zhang,
- Gui-Lin Hu,
- Chao Chu,
- Chao Chu,
- Yue-Yuan Liao,
- Yue-Yuan Liao,
- Chen Chen,
- Dan Wang,
- Dan Wang,
- Qiong Ma,
- Qiong Ma,
- Ke-Ke Wang,
- Ke-Ke Wang,
- Yue Sun,
- Yue Sun,
- Ze-Jiaxin Niu,
- Ze-Jiaxin Niu,
- Rui-Chen Yan,
- Rui-Chen Yan,
- Yu Yan,
- Yu Yan,
- Hao-Wei Zhou,
- Hao Jia,
- Wei-Hua Gao,
- Hao Li,
- Chun-Hua Li,
- Fang-Yao Chen,
- Ke Gao,
- Jie Zhang,
- Robert Safirstein,
- Feng Wang,
- Tie-Lin Yang,
- Jian-Jun Mu,
- Jian-Jun Mu
Affiliations
- Yang Wang
- Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
- Yang Wang
- Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi'an, China
- Ming-Fei Du
- Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
- Shi Yao
- Key Laboratory of Biomedical Information Engineering of Ministry of Education, Biomedical Informatics & Genomics Center, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China
- Ting Zou
- Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
- Xiao-Yu Zhang
- Department of Cardiology, Northwest Women's and Children's Hospital of Xi'an Jiaotong University Health Science Center, Xi'an, China
- Gui-Lin Hu
- Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
- Chao Chu
- Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
- Chao Chu
- Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi'an, China
- Yue-Yuan Liao
- Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
- Yue-Yuan Liao
- Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi'an, China
- Chen Chen
- Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
- Dan Wang
- Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
- Dan Wang
- Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi'an, China
- Qiong Ma
- Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
- Qiong Ma
- Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi'an, China
- Ke-Ke Wang
- Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
- Ke-Ke Wang
- Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi'an, China
- Yue Sun
- Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
- Yue Sun
- Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi'an, China
- Ze-Jiaxin Niu
- Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
- Ze-Jiaxin Niu
- Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi'an, China
- Rui-Chen Yan
- Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
- Rui-Chen Yan
- Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi'an, China
- Yu Yan
- Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
- Yu Yan
- Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi'an, China
- Hao-Wei Zhou
- Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
- Hao Jia
- Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
- Wei-Hua Gao
- Department of Cardiology, Xi'an No.1 Hospital, Xi'an, China
- Hao Li
- Department of Critical Care Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
- Chun-Hua Li
- Department of Ophthalmology, Xi'an People's Hospital, Xi'an, China
- Fang-Yao Chen
- Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China
- Ke Gao
- Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
- Jie Zhang
- Department of Cardiology, Xi'an People's Hospital, Xi'an, China
- Robert Safirstein
- 0Department of Medicine, Yale University School of Medicine, New Haven, CT, United States
- Feng Wang
- 1Department of Nephrology, Jiangsu University Affiliated Shanghai Eighth People's Hospital, Shanghai, China
- Tie-Lin Yang
- Key Laboratory of Biomedical Information Engineering of Ministry of Education, Biomedical Informatics & Genomics Center, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China
- Jian-Jun Mu
- Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
- Jian-Jun Mu
- Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi'an, China
- DOI
- https://doi.org/10.3389/fcvm.2021.710023
- Journal volume & issue
-
Vol. 8
Abstract
Background: Uromodulin, also named Tamm Horsfall protein, has been associated with renal function and regulation of sodium homeostasis. We aimed to examine the associations of serum uromodulin levels and its genetic variants with longitudinal blood pressure (BP) changes and hypertension incidence/risk.Methods: A total of 514 participants from the original Baoji Salt-Sensitive Study cohort were genotyped to examine the associations of genetic variations in uromodulin gene with the longitudinal BP changes and the incidence of hypertension over 8 years of follow-up. In addition, 2,210 subjects from the cohort of Hanzhong Adolescent Hypertension Study were used to investigate the relationships between serum uromodulin levels and the risk of hypertension.Results: SNPs rs12917707 and rs12708631 in the uromodulin gene were significantly associated with the longitudinal BP changes over 8 years of follow-up. SNP rs12708631 was significantly associated with the incidence of hypertension over 8 years. In addition, gene-based analyses supported the associations of uromodulin gene with the longitudinal BP changes and hypertension incidence in Baoji Salt-Sensitive Study cohort. Furthermore, serum uromodulin levels in the hypertensive subjects were lower than in the normotensive subjects (25.5 ± 1.1 vs. 34.7 ± 0.7 ng/mL). Serum uromodulin levels decreased gradually as BP levels increased (34.6, 33.2, 27.8, and 25.0 ng/mL for subjects with normotension, high-normal, grade 1 hypertension, and grade 2 hypertension, respectively). Serum uromodulin was significantly associated with the lower risk of hypertension [0.978 (0.972–0.984)] in Hanzhong Adolescent Hypertension Study cohort.Conclusion: This study shows that uromodulin is associated with blood pressure progression and development of hypertension.
Keywords
