Nature Communications (Aug 2019)
Glia-neuron interactions underlie state transitions to generalized seizures
- Carmen Diaz Verdugo,
- Sverre Myren-Svelstad,
- Ecem Aydin,
- Evelien Van Hoeymissen,
- Celine Deneubourg,
- Silke Vanderhaeghe,
- Julie Vancraeynest,
- Robbrecht Pelgrims,
- Mehmet Ilyas Cosacak,
- Akira Muto,
- Caghan Kizil,
- Koichi Kawakami,
- Nathalie Jurisch-Yaksi,
- Emre Yaksi
Affiliations
- Carmen Diaz Verdugo
- Faculty of Medicine and Health Sciences, Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology
- Sverre Myren-Svelstad
- Faculty of Medicine and Health Sciences, Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology
- Ecem Aydin
- Faculty of Medicine and Health Sciences, Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology
- Evelien Van Hoeymissen
- Faculty of Medicine and Health Sciences, Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology
- Celine Deneubourg
- Faculty of Medicine and Health Sciences, Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology
- Silke Vanderhaeghe
- Faculty of Medicine and Health Sciences, Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology
- Julie Vancraeynest
- Faculty of Medicine and Health Sciences, Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology
- Robbrecht Pelgrims
- Faculty of Medicine and Health Sciences, Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology
- Mehmet Ilyas Cosacak
- German Center for Neurodegenerative Diseases (DZNE) Dresden, Helmholtz Association / Technische Universität Dresden, Center for Molecular and Cellular Bioengineering (CMCB), Center for Regenerative Therapies Dresden (CRTD)
- Akira Muto
- Laboratory of Molecular and Developmental Biology, National Institute of Genetics, and Department of Genetics, SOKENDAI (The Graduate University for Advanced Studies), Mishima
- Caghan Kizil
- German Center for Neurodegenerative Diseases (DZNE) Dresden, Helmholtz Association / Technische Universität Dresden, Center for Molecular and Cellular Bioengineering (CMCB), Center for Regenerative Therapies Dresden (CRTD)
- Koichi Kawakami
- Laboratory of Molecular and Developmental Biology, National Institute of Genetics, and Department of Genetics, SOKENDAI (The Graduate University for Advanced Studies), Mishima
- Nathalie Jurisch-Yaksi
- Faculty of Medicine and Health Sciences, Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology
- Emre Yaksi
- Faculty of Medicine and Health Sciences, Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology
- DOI
- https://doi.org/10.1038/s41467-019-11739-z
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
During epileptic seizures, neural activity across the brain switches into a hyperactive and hypersynchronized state. Here, the authors report on the role of glia-glia and glia-neuron interactions in mediating the changes that result in the ictal state in a zebrafish model of epilepsy.
