International Journal of General Medicine (Feb 2022)

High Low-Density Lipoprotein Cholesterol Levels are Associated with Osteoporosis Among Adults 20–59 Years of Age

  • Xie R,
  • Huang X,
  • Zhang Y,
  • Liu Q,
  • Liu M

Journal volume & issue
Vol. Volume 15
pp. 2261 – 2270

Abstract

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Ruijie Xie,1 Xiongjie Huang,1 Ya Zhang,2 Qianlong Liu,3 Mingjiang Liu1 1Department of Hand Surgery, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, 421002, People’s Republic of China; 2Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, 533099, People’s Republic of China; 3The Affiliated Changsha Central Hospital, Hengyang Medical school, University of South China, Changsha, 410004, People’s Republic of ChinaCorrespondence: Mingjiang Liu, Email [email protected]: Serum lipids are highly inheritable and play a major role in bone health. However, the relationship between low-density lipoprotein cholesterol (LDL-C) and bone mineral density (BMD) remains uncertain. The goal of this study was to see if there was a link between LDL-C levels and BMD in persons aged 20 to 59.Methods: Using data from the National Health and Nutrition Examination Survey (NHANES) 2011– 2018, multivariate logistic regression models were utilized to investigate the association between LDL-C and lumbar BMD. Fitted smoothing curves and generalized additive models were also used.Results: The analysis included a total of 4909 adults. After controlling for various variables, we discovered that LDL-C was negatively linked with lumbar BMD. The favorable connection of LDL-C with lumbar BMD was maintained in subgroup analyses stratified by gender and race in both males and females, Whites and Mexican Americans, but not in Blacks and other races. The relationship between LDL-C and lumbar BMD in other races was an inverted U-shaped curve with the inflection point: 2.327 (mmol/L).Conclusion: In people aged 20 to 59, our research discovered a negative relationship among LDL-C and lumbar BMD. Among races other than Whites, Blacks, Mexican Americans, this relationship followed an inverted U-shaped curve (inflection point: 2.327mmol/L). LDL-C measurement might be used as a responsive biomarker for detecting osteoporosis early and guiding therapy.Keywords: low-density lipoprotein cholesterol, bone mineral density, osteoporosis, osteopenia

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