Nature Communications (Nov 2018)
Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing
- Chae Ho Lim,
- Qi Sun,
- Karan Ratti,
- Soung-Hoon Lee,
- Ying Zheng,
- Makoto Takeo,
- Wendy Lee,
- Piul Rabbani,
- Maksim V. Plikus,
- Jason E. Cain,
- David H. Wang,
- D. Neil Watkins,
- Sarah Millar,
- M. Mark Taketo,
- Peggy Myung,
- George Cotsarelis,
- Mayumi Ito
Affiliations
- Chae Ho Lim
- The Ronald O. Perelman Department of Dermatology and Department of Cell Biology, New York University School of Medicine
- Qi Sun
- The Ronald O. Perelman Department of Dermatology and Department of Cell Biology, New York University School of Medicine
- Karan Ratti
- The Ronald O. Perelman Department of Dermatology and Department of Cell Biology, New York University School of Medicine
- Soung-Hoon Lee
- The Ronald O. Perelman Department of Dermatology and Department of Cell Biology, New York University School of Medicine
- Ying Zheng
- Department of Dermatology and Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania
- Makoto Takeo
- The Ronald O. Perelman Department of Dermatology and Department of Cell Biology, New York University School of Medicine
- Wendy Lee
- The Ronald O. Perelman Department of Dermatology and Department of Cell Biology, New York University School of Medicine
- Piul Rabbani
- The Ronald O. Perelman Department of Dermatology and Department of Cell Biology, New York University School of Medicine
- Maksim V. Plikus
- Department of Developmental and Cell Biology, Irvine, Sue and Bill Gross Stem Cell Center, University of California
- Jason E. Cain
- Centre for Cancer Research, Hudson Institute for Medical Research and Department of Molecular and Translational Science, Faculty of Medicine, Nursing and Health Sciences, Monash University
- David H. Wang
- Division of Hematology and Oncology, Department of Internal Medicine, Harold C. Simmons Comprehensive Cancer Center, Esophageal Diseases Center, Medical Service, VA North Texas Health Care System, University of Texas Southwestern Medical Center
- D. Neil Watkins
- The Kinghorn Cancer Centre, Garvan Institute of Medical Research
- Sarah Millar
- Department of Dermatology and Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania
- M. Mark Taketo
- Division of Experimental Therapeutics, Graduate School of Medicine, Kyoto University
- Peggy Myung
- Departments of Dermatology and Pathology, School of Medicine, Yale University
- George Cotsarelis
- Department of Dermatology and Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania
- Mayumi Ito
- The Ronald O. Perelman Department of Dermatology and Department of Cell Biology, New York University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-018-07142-9
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
On wounding, scar formation in mammals arises causing no hair follicle regeneration, but it is unclear if scarring precludes regeneration. Here, the authors show that if Sonic hedgehog signaling is activated in the wound, an inductive dermal niche forms, enabling regeneration and hair follicle formation.
