EXPERIMENTAL STUDY OF GASTROPROTECTIVE ACTIVITY OF TRANSDERMAL ETHYLMETHYLHYDROXYPYRIDINE SUCCINATE

Abstract

We have carried out an experimental study of dose-dependent gastroprotective activity of transdermal plaster with ethylmethylhydroxypyridine succinate (mexidol), the purpose of which was the histological study of gastric mucosa, determination of lipid peroxidation (LP) in gastric tissue supernatant, weight study of thymus, spleen, and adrenals. Ethylmethylhydroxypyridine succinate has gastroprotective action in transdermal implementation at 20-75 mg/kg dose on the model of 18-hour immobilization of animals which had been starving for 24 hours.

Keywords

• 18-часовая иммобилизация
• трансдермальная терапевтическая система
• этилметнлгндроксипиридина сукцинат
• гастропротекторная активность