Neuron-astroglial interactions in dysregulation of energy metabolism in perinatal ischemic brain damage

Abstract

Presented is a review of the literature on the problem of hypoxic-ischemic perinatal brain damage in the context of alterations of astroglial regulation of neuronal energy metabolism and mechanisms of excitotoxicity. Characteristics of energy metabolism in the developing brain responsible for specificity of its damage in perinatal period, as well as cell and molecular mechanisms of disturbances of neuron-astrocyte coupling controlling regulation of neuroplasticity are discussed.

Keywords

• neuron
• astrocyte
• perinatal hypoxic-ischemic damage
• brain
• energy metabolism
• neuroplasticity