Genome-wide analysis in <i>Drosophila</i> reveals diet-by-gene interactions and uncovers diet-responsive genes

Abstract

AbstractGenetic and environmental factors play a major role in metabolic health. However, they do not act in isolation, as a change in an environmental factor such as diet may exert different effects based on an individual’s genotype. Here, we sought to understand how such gene–diet interactions influenced nutrient storage and utilization, a major determinant of metabolic disease. We subjected 178 inbred strains from the DrosophilaCG4607