Nature Communications (Aug 2018)
JunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin
Abstract
Epidermal homeostasis is maintained by the activity of stem cells. Here, the authors show that deficiency of the transcription factor JunB leads to altered Notch signaling in stem cells, resulting in a cell fate switch and de novo formation of aberrant sebaceous glands, altered epidermal differentiation and impaired barrier function.