Frontiers in Microbiology (Oct 2022)

Hemorrhagic fever viruses: Pathogenesis, therapeutics, and emerging and re-emerging potential

  • Lizdany Flórez-Álvarez,
  • Edmarcia Elisa de Souza,
  • Viviane Fongaro Botosso,
  • Danielle Bruna Leal de Oliveira,
  • Paulo Lee Ho,
  • Carlos Pelleschi Taborda,
  • Giuseppe Palmisano,
  • Margareth Lara Capurro,
  • João Renato Rebello Pinho,
  • João Renato Rebello Pinho,
  • Helena Lage Ferreira,
  • Paola Minoprio,
  • Eurico Arruda,
  • Luís Carlos de Souza Ferreira,
  • Luís Carlos de Souza Ferreira,
  • Carsten Wrenger,
  • Edison Luiz Durigon,
  • Edison Luiz Durigon

DOI
https://doi.org/10.3389/fmicb.2022.1040093
Journal volume & issue
Vol. 13

Abstract

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Hemorrhagic fever viruses (HFVs) pose a threat to global public health owing to the emergence and re-emergence of highly fatal diseases. Viral hemorrhagic fevers (VHFs) caused by these viruses are mostly characterized by an acute febrile syndrome with coagulation abnormalities and generalized hemorrhage that may lead to life-threatening organ dysfunction. Currently, the events underlying the viral pathogenicity associated with multiple organ dysfunction syndrome still underexplored. In this minireview, we address the current knowledge of the mechanisms underlying VHFs pathogenesis and discuss the available development of preventive and therapeutic options to treat these infections. Furthermore, we discuss the potential of HFVs to cause worldwide emergencies along with factors that favor their spread beyond their original niches.

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