Coumarinolignans with Reactive Oxygen Species (ROS) and NF-κB Inhibitory Activities from the Roots of <i>Waltheria indica</i>

Feifei Liu; Sudipta Mallick; Timothy J. O’Donnell; Ruxianguli Rouzimaimaiti; Yuheng Luo; Rui Sun; Marisa Wall; Supakit Wongwiwatthananukit; Abhijit Date; Dane Kaohelani Silva; Philip G. Williams; Leng Chee Chang

doi:10.3390/molecules27103270

Molecules (May 2022)

Coumarinolignans with Reactive Oxygen Species (ROS) and NF-κB Inhibitory Activities from the Roots of <i>Waltheria indica</i>

Feifei Liu,
Sudipta Mallick,
Timothy J. O’Donnell,
Ruxianguli Rouzimaimaiti,
Yuheng Luo,
Rui Sun,
Marisa Wall,
Supakit Wongwiwatthananukit,
Abhijit Date,
Dane Kaohelani Silva,
Philip G. Williams,
Leng Chee Chang

Affiliations

Feifei Liu: Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai‘i at Hilo, Hilo, HI 96720, USA
Sudipta Mallick: Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai‘i at Hilo, Hilo, HI 96720, USA
Timothy J. O’Donnell: Department of Chemistry, 2545 McCarthy Mall, University of Hawai‘i at Manoa, Honolulu, HI 96822, USA
Ruxianguli Rouzimaimaiti: Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai‘i at Hilo, Hilo, HI 96720, USA
Yuheng Luo: Department of Chemistry, 2545 McCarthy Mall, University of Hawai‘i at Manoa, Honolulu, HI 96822, USA
Rui Sun: Department of Chemistry, 2545 McCarthy Mall, University of Hawai‘i at Manoa, Honolulu, HI 96822, USA
Marisa Wall: Daniel K. Inouye U.S. Pacific Basin Agricultural Research Center, USDA-ARS, Hilo, HI 96720, USA
Supakit Wongwiwatthananukit: Department of Pharmacy Practice, Daniel K. Inouye College of Pharmacy, University of Hawai‘i at Hilo, Hilo, HI 96720, USA
Abhijit Date: Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai‘i at Hilo, Hilo, HI 96720, USA
Dane Kaohelani Silva: Hale Ola Pono, LLC, Keaau, HI 96749, USA
Philip G. Williams: Department of Chemistry, 2545 McCarthy Mall, University of Hawai‘i at Manoa, Honolulu, HI 96822, USA
Leng Chee Chang: Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai‘i at Hilo, Hilo, HI 96720, USA

DOI: https://doi.org/10.3390/molecules27103270
Journal volume & issue: Vol. 27, no. 10
p. 3270

Abstract

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Seven new coumarinolignans, walthindicins A–F (1a, 1b, 2–5, 7), along with five known analogs (6, 8–11), were isolated from the roots of Waltheria indica. The structures of the new compounds are determined by detailed nuclear magnetic resonance (NMR), circular dichroism (CD) with extensive computational support, and mass spectroscopic data interpretation. Compounds were tested for their antioxidant activity in Human Cervical Cancer cells (HeLa cells). Compounds 1a and 6 showed higher reactive oxygen species (ROS) inhibitory activity at 20 μg/mL when compared with other natural compound-based antioxidants such as ascorbic acid. Considering the role of ROS in nuclear-factor kappa B (NF-κB) activation, compounds 1a and 6 were evaluated for NF-κB inhibitory activity and showed a concentration-dependent inhibition in Human Embryonic Kidney 293 cells (Luc-HEK-293).

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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