Journal of Hematology & Oncology (Oct 2021)

HLA alleles associated with asparaginase hypersensitivity in Chinese children

  • Gilbert T. Chua,
  • Jaime S. Rosa Duque,
  • Daniel Ka Leung Cheuk,
  • Alex Wing Kwan Leung,
  • Wilfred Hing Sang Wong,
  • Anthony Pak Yin Liu,
  • Pamela P. W. Lee,
  • Shau Yin Ha,
  • Alan Kwok Shing Chiang,
  • Marco Hok Kung Ho,
  • Wai Keung Chu,
  • Yuk Sing Chan,
  • Chun Wing Luk,
  • Alvin Siu Cheung Ling,
  • Mike Yat Wah Kwan,
  • Oscar Kuen Fong Yiu,
  • Ian Chi Kei Wong,
  • Yu Lung Lau,
  • Chi Kong Li,
  • Wing Hang Leung,
  • Godfrey Chi Fung Chan,
  • Patrick Ip,
  • Janette Kwok

DOI
https://doi.org/10.1186/s13045-021-01201-3
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 4

Abstract

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Abstract Asparaginase is an important drug to treat childhood haematological malignancies. Data on the association between human leukocyte antigens (HLA) and asparaginase hypersensitivity among Chinese are lacking. We conducted a retrospective study to identify HLA alleles associated with asparaginase hypersensitivity among Chinese children with acute lymphoblastic leukaemia (ALL), mixed phenotype leukaemia and non-Hodgkin lymphoma (NHL), who received asparaginases with HLA typing performed between 2009 and 2019. 107 Chinese patients were analysed. 66.3% (71/107) developed hypersensitivity to at least one of the asparaginases. HLA-B*46:01 (OR 3.8, 95% CI 1.4–10.1, p < 0.01) and DRB1*09:01 (OR 4.3, 95% CI 1.6–11.4, p < 0.01) were significantly associated with l-asparaginase hypersensitivities, which remained significant after adjustment for age, gender and B cell ALL [HLA-B*46:01 (adjusted OR 3.5, 95% 1.3–10.5, p = 0.02) and DRB1*09:01 (OR 4.4, 95% CI 1.6–13.3, p < 0.01)].

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