Cyclic Bis-1,3-dialkylpyridiniums from the Sponge <em>Haliclona</em> sp.

Abstract

Eight novel cyclic bis-1,3-dialkylpyridiniums, as well as two known compounds from the cyclostellettamine class, were isolated from the sponge <em>Haliclona</em> sp. from Korea. Structures of these novel compounds were determined using combined NMR and FAB-MS/MS analyses. Several of these compounds exhibited moderate cytotoxic and antibacterial activities against A549 cell-line and Gram-positive strains, respectively. The structure-activity relationships of cyclostellettamines are discussed based on their bioactivities.

Keywords

• &lt;em&gt;Haliclona&lt;/em&gt; sp.
• bis-1,3-dialkylpyridiniums
• cyclostellettamines
• cytotoxicity
• antimicrobial activity