ANGIOTENSIN CONVERTING ENZIME GENE I/D POLYMORPHISM AND PROMISSING OF RENOPROTECTIVE AND IMMUNOSUPRESSIVE THERAPY IN CHILDREN WITH NEPHROTIC SYNDROME

Abstract

To investigate the role of i/d polymorphism gene angiotensin converting enzyme (ACE) in promissing of renoprotective and immunosupressive therapy in children with nephrotic syndrome syndrome (NS) we determined the genotypes of ACE in 76 children with ns including 22 children with chronic renal failure (CRF). the analysis of treatment effect with inhibitor ace in patients with steroid resistant ns (SRNS) demonstrated decreasing of renoprotective effect of these drugs in patients with DD genotype compared with ii and id genotypes (р = 0,033) by similar degree of the glomerular filtration rate (GFR), proteinuria and blood pressure decrease in these patients. Percentage of DD genotype in patients with ns refractory to therapy of cyclosporin a were height compared with patients, sensitive to this therapy.Key words: nephrotic syndrome, chronic renal failure, polymorphism of genes, renin-angiotensin system.