New Palladium(II) Complexes Containing Methyl Gallate and Octyl Gallate: Effect against <i>Mycobacterium tuberculosis</i> and <i>Campylobacter jejuni</i>
Raphael Tristão Cruvinel Silva,
Micaela Guidotti-Takeuchi,
Jéssica Laura Miranda Peixoto,
Fernanda Manaia Demarqui,
Ananda Paula Mori,
Carolyne Ferreira Dumont,
Gabriella Rayane Aparecida Ferreira,
Gabriele de Menezes Pereira,
Daise Aparecida Rossi,
Pedro Paulo Corbi,
Fernando Rogério Pavan,
Celso de Oliveira Rezende Júnior,
Roberta Torres de Melo,
Wendell Guerra
Affiliations
Raphael Tristão Cruvinel Silva
Institute of Chemistry, Federal University of Uberlândia—UFU, Santa Mônica Campus, Uberlândia 38402-018, MG, Brazil
Micaela Guidotti-Takeuchi
Laboratory of Experimental Molecular Epidemiology, Federal University of Uberlândia—UFU, Umuarama Campus, Uberlândia 87504-000, MG, Brazil
Jéssica Laura Miranda Peixoto
Laboratory of Experimental Molecular Epidemiology, Federal University of Uberlândia—UFU, Umuarama Campus, Uberlândia 87504-000, MG, Brazil
Fernanda Manaia Demarqui
Faculty of Pharmaceutical Sciences, Paulista State University—UNESP, Araraquara Campus, Araraquara 14800-060, SP, Brazil
Ananda Paula Mori
Institute of Chemistry, Federal University of Uberlândia—UFU, Santa Mônica Campus, Uberlândia 38402-018, MG, Brazil
Carolyne Ferreira Dumont
Laboratory of Experimental Molecular Epidemiology, Federal University of Uberlândia—UFU, Umuarama Campus, Uberlândia 87504-000, MG, Brazil
Gabriella Rayane Aparecida Ferreira
Laboratory of Experimental Molecular Epidemiology, Federal University of Uberlândia—UFU, Umuarama Campus, Uberlândia 87504-000, MG, Brazil
Gabriele de Menezes Pereira
Institute of Chemistry, State University of Campinas—UNICAMP, Campinas 13083-872, SP, Brazil
Daise Aparecida Rossi
Laboratory of Experimental Molecular Epidemiology, Federal University of Uberlândia—UFU, Umuarama Campus, Uberlândia 87504-000, MG, Brazil
Pedro Paulo Corbi
Institute of Chemistry, State University of Campinas—UNICAMP, Campinas 13083-872, SP, Brazil
Fernando Rogério Pavan
Faculty of Pharmaceutical Sciences, Paulista State University—UNESP, Araraquara Campus, Araraquara 14800-060, SP, Brazil
Celso de Oliveira Rezende Júnior
Institute of Chemistry, Federal University of Uberlândia—UFU, Santa Mônica Campus, Uberlândia 38402-018, MG, Brazil
Roberta Torres de Melo
Laboratory of Experimental Molecular Epidemiology, Federal University of Uberlândia—UFU, Umuarama Campus, Uberlândia 87504-000, MG, Brazil
Wendell Guerra
Institute of Chemistry, Federal University of Uberlândia—UFU, Santa Mônica Campus, Uberlândia 38402-018, MG, Brazil
This work describes the preparation, characterization and antimicrobial activity of four palladium(II) complexes, namely, [Pd(meg)(1,10-phen)] 1, [Pd(meg)(PPh3)2] 2, [Pd(og)(1,10-phen)] 3 and [Pd(og)(PPh3)2] 4, where meg = methyl gallate, og = octyl gallate, 1,10-phen = 1,10-phenanthroline and PPh3 = triphenylphosphine. As to the chemical structures, spectral and physicochemical studies of 1–4 indicated that methyl or octyl gallate coordinates a palladium(II) ion through two oxygen atoms upon deprotonation. A chelating bidentate phenanthroline or two triphenylphosphine molecules complete the coordination sphere of palladium(II) ion, depending on the complex. The metal complexes were tested against the Mycobacterium tuberculosis H37Rv strain and 2 exhibited high activity (MIC = 3.28 μg/mL). As to the tests with Campylobacter jejuni, complex 1 showed a significant effect in reducing bacterial population (greater than 7 log CFU) in planktonic forms, as well as in the biomass intensity (IBF: 0.87) when compared to peracetic acid (IBF: 1.11) at a concentration of 400 μg/mL. The effect provided by these complexes has specificity according to the target microorganism and represent a promising alternative for the control of microorganisms of public health importance.
