Nature Communications (Apr 2020)

Quantitative proteomic landscape of metaplastic breast carcinoma pathological subtypes and their relationship to triple-negative tumors

  • Sabra I. Djomehri,
  • Maria E. Gonzalez,
  • Felipe da Veiga Leprevost,
  • Shilpa R. Tekula,
  • Hui-Yin Chang,
  • Marissa J. White,
  • Ashley Cimino-Mathews,
  • Boris Burman,
  • Venkatesha Basrur,
  • Pedram Argani,
  • Alexey I. Nesvizhskii,
  • Celina G. Kleer

DOI
https://doi.org/10.1038/s41467-020-15283-z
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 15

Abstract

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Metaplastic breast carcinoma (MBC) is among the most aggressive subtypes of triple-negative breast cancer (TNBC) but the underlying proteome profiles are unknown. Here, the authors characterize the protein signatures of human MBC tissue samples and their relationship to TNBC and normal breast tissue.