Nature Communications (May 2018)
Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis
- Sean P. Pitroda,
- Nikolai N. Khodarev,
- Lei Huang,
- Abhineet Uppal,
- Sean C. Wightman,
- Sabha Ganai,
- Nora Joseph,
- Jason Pitt,
- Miguel Brown,
- Martin Forde,
- Kathy Mangold,
- Lai Xue,
- Christopher Weber,
- Jeremy P. Segal,
- Sabah Kadri,
- Melinda E. Stack,
- Sajid Khan,
- Philip Paty,
- Karen Kaul,
- Jorge Andrade,
- Kevin P. White,
- Mark Talamonti,
- Mitchell C. Posner,
- Samuel Hellman,
- Ralph R. Weichselbaum
Affiliations
- Sean P. Pitroda
- Department of Radiation and Cellular Oncology, The University of Chicago
- Nikolai N. Khodarev
- Department of Radiation and Cellular Oncology, The University of Chicago
- Lei Huang
- Center for Research Informatics, The University of Chicago
- Abhineet Uppal
- Department of Surgery, The University of Chicago
- Sean C. Wightman
- Department of Surgery, The University of Chicago
- Sabha Ganai
- Department of Surgery, Southern Illinois University
- Nora Joseph
- Department of Pathology, NorthShore University Hospital
- Jason Pitt
- Institute for Genomics and Systems Biology, The University of Chicago
- Miguel Brown
- Institute for Genomics and Systems Biology, The University of Chicago
- Martin Forde
- Institute for Genomics and Systems Biology, The University of Chicago
- Kathy Mangold
- Department of Pathology, NorthShore University Hospital
- Lai Xue
- Department of Surgery, The University of Chicago
- Christopher Weber
- Department of Pathology, The University of Chicago
- Jeremy P. Segal
- Department of Pathology, The University of Chicago
- Sabah Kadri
- Department of Pathology, The University of Chicago
- Melinda E. Stack
- Department of Surgery, The University of Chicago
- Sajid Khan
- Department of Surgery, Yale School of Medicine
- Philip Paty
- Department of Surgery, Memorial Sloan-Kettering Cancer Center
- Karen Kaul
- Department of Pathology, NorthShore University Hospital
- Jorge Andrade
- Center for Research Informatics, The University of Chicago
- Kevin P. White
- Institute for Genomics and Systems Biology, The University of Chicago
- Mark Talamonti
- Department of Surgery, NorthShore University Hospital
- Mitchell C. Posner
- Department of Surgery, The University of Chicago
- Samuel Hellman
- Department of Radiation and Cellular Oncology, The University of Chicago
- Ralph R. Weichselbaum
- Department of Radiation and Cellular Oncology, The University of Chicago
- DOI
- https://doi.org/10.1038/s41467-018-04278-6
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 8
Abstract
The oligometastasis hypothesis suggests certain metastases are limited in extent and curable with focal therapies. Here they identify three integrated molecular subtypes of colorectal cancer liver metastasis, which complement clinical risk stratification to distinguish the subset of oligometastatic patients.
