Nature Communications (Feb 2021)

Control of oviductal fluid flow by the G-protein coupled receptor Adgrd1 is essential for murine embryo transit

  • Enrica Bianchi,
  • Yi Sun,
  • Alexandra Almansa-Ordonez,
  • Michael Woods,
  • David Goulding,
  • Nadia Martinez-Martin,
  • Gavin J. Wright

DOI
https://doi.org/10.1038/s41467-021-21512-w
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

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Lack of correct embryo transport can cause ectopic pregnancy. Here, the authors show that female mice lacking the adhesion G-protein coupled receptor Adgrd1 are infertile, due to embryos being trapped in the ampulla as the result of dysregulated oviductal fluid flow.