A scalable peptide-GPCR language for engineering multicellular communication

Sonja Billerbeck; James Brisbois; Neta Agmon; Miguel Jimenez; Jasmine Temple; Michael Shen; Jef D. Boeke; Virginia W. Cornish

doi:10.1038/s41467-018-07610-2

Nature Communications (Nov 2018)

A scalable peptide-GPCR language for engineering multicellular communication

Sonja Billerbeck,
James Brisbois,
Neta Agmon,
Miguel Jimenez,
Jasmine Temple,
Michael Shen,
Jef D. Boeke,
Virginia W. Cornish

Affiliations

Sonja Billerbeck: Department of Chemistry, Columbia University
James Brisbois: Department of Chemistry, Columbia University
Neta Agmon: Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health
Miguel Jimenez: Department of Chemistry, Columbia University
Jasmine Temple: Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health
Michael Shen: Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health
Jef D. Boeke: Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health
Virginia W. Cornish: Department of Chemistry, Columbia University

DOI: https://doi.org/10.1038/s41467-018-07610-2
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

Read online

A bottleneck to engineered multicellular systems is the lack of a scalable signalling language. Here the authors use fungal mating peptide and GPCR pairs to build functional cell-to-cell communication links.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal