Magnetic Bead Manipulation in Microfluidic Chips for Biological Application

Gaozhe Cai; Zixin Yang; Yu-Cheng Chen; Yaru Huang; Lijuan Liang; Shilun Feng; Jianlong Zhao

doi:10.34133/cbsystems.0023

Cyborg and Bionic Systems (Jan 2023)

Magnetic Bead Manipulation in Microfluidic Chips for Biological Application

Gaozhe Cai,
Zixin Yang,
Yu-Cheng Chen,
Yaru Huang,
Lijuan Liang,
Shilun Feng,
Jianlong Zhao

Affiliations

Gaozhe Cai: State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China.
Zixin Yang: School of Communication and Information Engineering, Shanghai University, Shanghai 200444, China.
Yu-Cheng Chen: School of Electrical and Electronics Engineering, Nanyang Technological University, 50 Nanyang Ave., Singapore 639798, Singapore.
Yaru Huang: State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China.
Lijuan Liang: State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China.
Shilun Feng: State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China.
Jianlong Zhao: State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China.

DOI: https://doi.org/10.34133/cbsystems.0023
Journal volume & issue: Vol. 4

Abstract

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Magnetic beads manipulation in microfluidic chips is a promising research field for biological application, especially in the detection of biological targets. In this review, we intend to present a thorough and in-depth overview of recent magnetic beads manipulation in microfluidic chips and its biological application. First, we introduce the mechanism of magnetic manipulation in microfluidic chip, including force analysis, particle properties, and surface modification. Then, we compare some existing methods of magnetic manipulation in microfluidic chip and list their biological application. Besides, the suggestions and outlook for future developments in the magnetic manipulation system are also discussed and summarized.

Published in Cyborg and Bionic Systems

ISSN: 2692-7632 (Online)
Publisher: American Association for the Advancement of Science (AAAS)
Country of publisher: United States
LCC subjects: Science: Science (General): Cybernetics
Website: https://spj.sciencemag.org/journals/cbsystems/

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