Clinical, Cosmetic and Investigational Dermatology (Feb 2024)

Polynucleotides HPT for Asian Skin Regeneration and Rejuvenation

  • Lim TS,
  • Liew S,
  • Tee XJ,
  • Chong I,
  • Lo FJ,
  • Ho MJ,
  • Ong K,
  • Cavallini M

Journal volume & issue
Vol. Volume 17
pp. 417 – 431

Abstract

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Ting Song Lim,1 ShaoRong Liew,1 Xiang Jie Tee,1 Ian Chong,1 Fui Jun Lo,1 Meng Jun Ho,1 KuokTjun Ong,1 Maurizio Cavallini2 1Clique Clinic, Petaling Jaya, Selangor, Malaysia; 2Dermatology and Dermatosurgery Department, CDI Centro Diagnostico Italiano, Milan, ItalyCorrespondence: Ting Song Lim, Clique Clinic, 4, Jalan 19/36, Seksyen 19, Petaling Jaya, Selangor, 46300, Malaysia, Email [email protected]: Even lightly compromised skin may impact self-esteem and social behaviour. After intradermal infiltration, natural-origin Polynucleotides High Purification Technology (PN HPT) promote new collagen and extracellular matrix production, translating into a physiological correction of the ageing skin. The study aimed to explore the benefits of intradermal PN HPT on the four perceptual skin quality categories “Skin Tone Evenness”, “Skin Surface Evenness”, “Skin Firmness”, and “Skin Glow” in a representative sample of 30 Asian subjects (mean age 40.2± 11.4 years old).Methods: Study protocol: three intradermal injections of a PN HPT-based Class III CE-marked medical device at T0 (baseline assessment and first treatment session), T1 (four weeks after baseline), and T2 (eight weeks after baseline), with efficacy and safety evaluations at T1, T2, T3 (four months after baseline) and T4 (six months after baseline). Quantitative and qualitative assessments: 3D skin analysis system QuantifiCare and Global Aesthetic Improvement Scale (GAIS, Investigator and Patient subscales).Results: PN HPT treatment led to a meaningful and statistically significant improvement of the skin surface, firmness, pigmentation, and radiance, with no early- or late-onset adverse events and benefits persisting up to the sixth-month visit in all subjects. At T4, 33% and 43% of treated subjects felt “Much Improved” and “Very Much Improved” (optimal result); 56% and 44% of treated subjects felt “Satisfied” or “Very Satisfied”. At T4, the mean Investigator GAIS scores were 3.33 out of 5.0 for the “Skin Tone Evenness” skin quality perceptual category, 3.46 for the “Skin Surface Evenness” category, 3.61 for “Skin Firmness”, and 3.45 per for the radiance determinant of the “Skin Glow” category.Conclusion: Intradermal treatment with the PN HPT-based medical device led to a meaningful improvement of the skin surface, firmness, pigmentation, and radiance with complete safety. The aesthetic benefits persisted up to the sixth-month visit in all subjects.Keywords: emergent perceptual skin quality categories, EPCs, GAIS, global aesthetic improvement scale, polynucleotides HPT, PN HPT, QuantifiCare, skin quality

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