Nature Communications (Mar 2018)
Counterregulation of cAMP-directed kinase activities controls ciliogenesis
- Monia Porpora,
- Simona Sauchella,
- Laura Rinaldi,
- Rossella Delle Donne,
- Maria Sepe,
- Omar Torres-Quesada,
- Daniela Intartaglia,
- Corrado Garbi,
- Luigi Insabato,
- Margherita Santoriello,
- Verena A. Bachmann,
- Matthis Synofzik,
- Herbert H. Lindner,
- Ivan Conte,
- Eduard Stefan,
- Antonio Feliciello
Affiliations
- Monia Porpora
- Department of Molecular Medicine and Medical Biotechnologies, University ‘Federico II’
- Simona Sauchella
- Department of Molecular Medicine and Medical Biotechnologies, University ‘Federico II’
- Laura Rinaldi
- Department of Molecular Medicine and Medical Biotechnologies, University ‘Federico II’
- Rossella Delle Donne
- Department of Molecular Medicine and Medical Biotechnologies, University ‘Federico II’
- Maria Sepe
- Department of Molecular Medicine and Medical Biotechnologies, University ‘Federico II’
- Omar Torres-Quesada
- Institute of Biochemistry and Center for Molecular Biosciences Innsbruck, University of Innsbruck
- Daniela Intartaglia
- Telethon Institute of Genetics and Medicine
- Corrado Garbi
- Department of Molecular Medicine and Medical Biotechnologies, University ‘Federico II’
- Luigi Insabato
- Department of Advanced Biomedical Sciences, University Federico II
- Margherita Santoriello
- Department of Molecular Medicine and Medical Biotechnologies, University ‘Federico II’
- Verena A. Bachmann
- Institute of Biochemistry and Center for Molecular Biosciences Innsbruck, University of Innsbruck
- Matthis Synofzik
- Department of Neurodegeneration, Hertie Institute for Clinical Brain Research (HIH), University of Tübingen and German Center for Neurodegenerative Diseases (DZNE)
- Herbert H. Lindner
- Division of Clinical Biochemistry, Biocenter Medical University of Innsbruck
- Ivan Conte
- Telethon Institute of Genetics and Medicine
- Eduard Stefan
- Institute of Biochemistry and Center for Molecular Biosciences Innsbruck, University of Innsbruck
- Antonio Feliciello
- Department of Molecular Medicine and Medical Biotechnologies, University ‘Federico II’
- DOI
- https://doi.org/10.1038/s41467-018-03643-9
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
The mechanisms that control ciliogenesis have been extensively explored however the signaling mechanisms that control cilium stability remain unclear. Here the authors show that GPCR signaling regulates cilia resorption via the ubiquitin-proteasome system.
