Frontiers in Oncology (Oct 2023)
Novel therapeutic approaches for pediatric diencephalic tumors: improving functional outcomes
- Julia V. Cockle,
- Julia V. Cockle,
- Elizabeth A. Corley,
- Bassel Zebian,
- Samantha Hettige,
- Sucheta J. Vaidya,
- Paola Angelini,
- Paola Angelini,
- Joanna Stone,
- R Jane Leitch,
- Assunta Albanese,
- Assunta Albanese,
- Henry C. Mandeville,
- Henry C. Mandeville,
- Henry C. Mandeville,
- Fernando Carceller,
- Fernando Carceller,
- Fernando Carceller,
- Lynley V. Marshall,
- Lynley V. Marshall,
- Lynley V. Marshall
Affiliations
- Julia V. Cockle
- Department of Neuro-oncology, Children and Young People’s Unit, The Royal Marsden National Health Service (NHS) Foundation Trust, London, United Kingdom
- Julia V. Cockle
- Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom
- Elizabeth A. Corley
- Pediatric and Adolescent Oncology Drug Development Team, Children and Young People’s Unit, The Royal Marsden National Health Service (NHS) Foundation Trust, London, United Kingdom
- Bassel Zebian
- Department of Neurosurgery, Kings College Hospital National Health Service (NHS) Trust, London, United Kingdom
- Samantha Hettige
- Atkinson Morley Neurosurgery Centre, St George’s University Hospital National Health Service (NHS) Foundation Trust, London, United Kingdom
- Sucheta J. Vaidya
- Department of Neuro-oncology, Children and Young People’s Unit, The Royal Marsden National Health Service (NHS) Foundation Trust, London, United Kingdom
- Paola Angelini
- Department of Neuro-oncology, Children and Young People’s Unit, The Royal Marsden National Health Service (NHS) Foundation Trust, London, United Kingdom
- Paola Angelini
- Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom
- Joanna Stone
- Department of Neuro-oncology, Children and Young People’s Unit, The Royal Marsden National Health Service (NHS) Foundation Trust, London, United Kingdom
- R Jane Leitch
- Department of Ophthalmology, Epsom and St Hellier University Hospitals Trust, Carshalton, United Kingdom
- Assunta Albanese
- Department of Neuro-oncology, Children and Young People’s Unit, The Royal Marsden National Health Service (NHS) Foundation Trust, London, United Kingdom
- Assunta Albanese
- Department of Pediatric Endocrinology, The Royal Marsden National Health Service (NHS) Foundation Trust, London, United Kingdom
- Henry C. Mandeville
- Department of Neuro-oncology, Children and Young People’s Unit, The Royal Marsden National Health Service (NHS) Foundation Trust, London, United Kingdom
- Henry C. Mandeville
- Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom
- Henry C. Mandeville
- Department of Radiotherapy, The Royal Marsden National Health Service (NHS) Foundation Trust, London, United Kingdom
- Fernando Carceller
- Department of Neuro-oncology, Children and Young People’s Unit, The Royal Marsden National Health Service (NHS) Foundation Trust, London, United Kingdom
- Fernando Carceller
- Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom
- Fernando Carceller
- Pediatric and Adolescent Oncology Drug Development Team, Children and Young People’s Unit, The Royal Marsden National Health Service (NHS) Foundation Trust, London, United Kingdom
- Lynley V. Marshall
- Department of Neuro-oncology, Children and Young People’s Unit, The Royal Marsden National Health Service (NHS) Foundation Trust, London, United Kingdom
- Lynley V. Marshall
- Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom
- Lynley V. Marshall
- Pediatric and Adolescent Oncology Drug Development Team, Children and Young People’s Unit, The Royal Marsden National Health Service (NHS) Foundation Trust, London, United Kingdom
- DOI
- https://doi.org/10.3389/fonc.2023.1178553
- Journal volume & issue
-
Vol. 13
Abstract
Pediatric diencephalic tumors represent a histopathologically and molecularly diverse group of neoplasms arising in the central part of the brain and involving eloquent structures, including the hypothalamic-pituitary axis (HPA), optic pathway, thalamus, and pineal gland. Presenting symptoms can include significant neurological, endocrine, or visual manifestations which may be exacerbated by injudicious intervention. Upfront multidisciplinary assessment and coordinated management is crucial from the outset to ensure best short- and long-term functional outcomes. In this review we discuss the clinical and pathological features of the neoplastic entities arising in this location, and their management. We emphasize a clear move towards ‘function preserving’ diagnostic and therapeutic approaches with novel toxicity-sparing strategies, including targeted therapies.
Keywords
- pediatric diencephalic tumors
- glioma
- craniopharyngioma
- germ cell tumor
- Langerhans cell histiocytosis
- molecularly targeted therapies
